Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Edward K Chapnick; Jeremy D Gradon; Larry I  Lutwick; John Kim; Michael Levi; Michael H Kim; Patrick M Schlievert

doi:10.1093/clinids/14.5.1074

Back

Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Journal article

Open access

Peer reviewed

Streptococcal toxic shock syndrome due to noninvasive pharyngitis

Edward K Chapnick, Jeremy D Gradon, Larry I Lutwick, John Kim, Michael Levi, Michael H Kim and Patrick M Schlievert

Clinical infectious diseases, Vol.14(5), pp.1074-1077

05/1992

DOI: 10.1093/clinids/14.5.1074

PMID: 1600009

Files and links (1)

url

https://doi.org/10.1093/clinids/14.5.1074View

Published (Version of record) Open Access

Abstract

Serious infections due to group A beta-hemolytic streptococcus (GABHS) have been reported with increasing frequency in recent years. We report a case of toxic shock syndrome (TSS) due to GABHS pharyngitis in an otherwise healthy 14-year-old boy. The organism was found to produce toxin A. To our knowledge, this is the second reported case of streptococcal TSS associated with the production of toxin A that is not associated with an invasive disease and the first case associated with a documented rise in the level of antibody to the streptococcal toxin itself. Clinicians must be especially vigilant for this entity in patients who have streptococcal pharyngitis because early recognition and institution of aggressive supportive therapy can be lifesaving.

Membrane Proteins

Pharyngitis - complications

Streptococcus pyogenes - isolation & purification

Exotoxins - biosynthesis

Shock, Septic - etiology

Humans

Adolescent

Male

Streptococcal Infections - complications

Streptococcus pyogenes - metabolism

Bacterial Proteins

Details

Title: Subtitle: Streptococcal toxic shock syndrome due to noninvasive pharyngitis
Creators: Edward K Chapnick - Department of Medicine, Maimonides Medical Center, Brooklyn, New York 11219
Jeremy D Gradon
Larry I Lutwick
John Kim
Michael Levi
Michael H Kim
Patrick M Schlievert
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.14(5), pp.1074-1077
DOI: 10.1093/clinids/14.5.1074
PMID: 1600009
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: United States
Language: English
Date published: 05/1992
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001223502771

Metrics

26 Record Views

44 Times Cited - Web of Science

See more details