Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling

Qiujun Huang; Hiroyuki Oya; Oliver Flouty; Chandan Reddy; Matthew Howard III; George Gillies; Marcel Utz

doi:10.1007/s11517-014-1157-7

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Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling

Journal article

Peer reviewed

Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling

Qiujun Huang, Hiroyuki Oya, Oliver Flouty, Chandan Reddy, Matthew Howard III, George Gillies and Marcel Utz

Medical & biological engineering & computing, Vol.52(6), pp.531-538

06/2014

DOI: 10.1007/s11517-014-1157-7

PMID: 24771203

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Abstract

Spinal cord stimulation currently relies on extradural electrode arrays that are separated from the spinal cord surface by a highly conducting layer of cerebrospinal fluid. It has recently been suggested that intradural placement of the electrodes in direct contact with the pial surface could greatly enhance the specificity and efficiency of stimulation. The present computational study aims at quantifying and comparing the electrical current distributions as well as the spatial recruitment profiles resulting from extra- and intra-dural electrode arrangements. The electrical potential distribution is calculated using a 3D finite element model of the human thoracic spinal canal. The likely recruitment areas are then obtained using the potential as input to an equivalent circuit model of the pre-threshold axonal response. The results show that the current threshold to recruitment of axons in the dorsal column is more than an order of magnitude smaller for intradural than extradural stimulation. Intradural placement of the electrodes also leads to much higher contrast between the stimulation thresholds for the dorsal root entry zone and the dorsal column, allowing better focusing of the stimulus.

Biomedical Engineering

Computer Applications

Human Physiology

Biomedicine

Simulation

Spinal cord stimulation

Intradural

Imaging / Radiology

Details

Title: Subtitle: Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling
Creators: Qiujun Huang - Department of Mechanical Engineering University of Virginia Charlottesville VA 22903 USA
Hiroyuki Oya - Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA 52242 USA
Oliver Flouty - Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA 52242 USA
Chandan Reddy - Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA 52242 USA
Matthew Howard III - Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA 52242 USA
George Gillies - Department of Mechanical Engineering University of Virginia Charlottesville VA 22903 USA
Marcel Utz - School of Chemistry University of Southampton Southampton SO17 1BJ UK
Resource Type: Journal article
Publication Details: Medical & biological engineering & computing, Vol.52(6), pp.531-538
DOI: 10.1007/s11517-014-1157-7
PMID: 24771203
NLM abbreviation: Med Biol Eng Comput
ISSN: 0140-0118
eISSN: 1741-0444
Publisher: Springer Berlin Heidelberg; Berlin/Heidelberg
Language: English
Date published: 06/2014
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984013918602771

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