Journal article
Primary central nervous system Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases
Brain tumor pathology, Vol.31(4), pp.265-273
10/2014
DOI: 10.1007/s10014-013-0173-x
PMID: 24399201
Abstract
We report five cases of primary central nervous system (CNS) Epstein–Barr virus (EBV)-positive lymphoma of the elderly. This represented an incidence of 4 % of primary CNS diffuse large B-cell lymphoma (DLBCL) after EBV screening in 134 cases. All five patients were 65 years or older with no previous history of congenital or iatrogenic immune deficiencies. The histologic morphology of all the cases was DLBCL, with variable amounts of necrosis. The cell of origin (COO) as determined by the Hans algorithm disclosed germinal center type in 2 cases and non-germinal center type in 3 cases. MYC translocation was not detected, and MYC overexpression was detected in only one case. Three patients died shortly after diagnosis, and the remaining 2 patients were in complete remission for 2 and 10 years, respectively. We conclude that EBV+ DLBCL among the elderly is uncommon in primary CNS lymphoma in the Eastern United States. The patients usually present with a single mass lesion with headache and sensorimotor symptoms. The histologic morphology is DLBCL, but clonal T-cell gene rearrangement may be detected. The outcome varies from case to case and appears to be unrelated to the COO or MYC status.
Details
- Title: Subtitle
- Primary central nervous system Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases
- Creators
- Siraj Jamal - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USAShiyong Li - Department of Pathology and Laboratory Medicine Emory University Atlanta USARenu Bajaj - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USAZixuan Wang - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USALawrence Kenyon - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USAJon Glass - Jefferson Hospital for Neuroscience Thomas Jefferson University Philadelphia USAChanglee Pang - Department of Pathology Wake Forest University Winston-Salem USASharathkumar Bhagavathi - Department of Pathology University of Medicine and Dentistry New Jersey New Brunswick USAStephen Peiper - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USAJerald Gong - Department of Pathology, Anatomy and Cell Biology Thomas Jefferson University Philadelphia USA
- Resource Type
- Journal article
- Publication Details
- Brain tumor pathology, Vol.31(4), pp.265-273
- Publisher
- Springer Japan; Tokyo
- DOI
- 10.1007/s10014-013-0173-x
- PMID
- 24399201
- ISSN
- 1433-7398
- eISSN
- 1861-387X
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Pathology
- Record Identifier
- 9984047775402771
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