Abstract
88. Psychological resilience is associated with markers of inflammation and angiogenesis in pre-surgical ovarian cancer patients
Brain, behavior, and immunity, Vol.26, pp.S25-S25
09/2012
DOI: 10.1016/j.bbi.2012.07.112
Abstract
Although psychological distress has been linked to biological processes that may promote ovarian cancer, little is known about the role that psychological resilience plays in this context. To address this issue, we examined how scores on a multi-faceted index of psychological resilience related to biomarkers of inflammation (interleukin-6; IL-6) and angiogenesis (vascular endothelial growth factor; VEGF) in a sample of 200 ovarian cancer patients assessed prior to diagnostic surgery. Using confirmatory factor analysis, a psychological resilience factor with the best fit was determined (Chi-square=7.28, p=.20; RMSEA=0.05; CFI=0.99; TLI=0.98). Factors included in the measurement model as indicators of resilience include psychological well-being (Psychological Well-Being Scales), positive affect (CESD-D positive affect subscale), and the spiritual, emotional, and functional well-being subscales of the Functional Assessment of Cancer Therapy scale. This psychological resilience index was then used in a structural equation model with IL-6 and VEGF regressed on the latent variable, controlling for cancer stage and grade, age, BMI, and fatigue. Greater psychological resilience was significantly associated with lower levels of IL-6 (beta=−0.20, SE=.09, p=0.026) but was unrelated to levels of VEGF (beta=−0.11, SE=.09, p=.241). This suggests that protective psychological factors may be linked to inflammatory biology in ovarian cancer. Additional research is needed to examine how psychological risk and resilience factors interact to predict clinical outcomes in ovarian cancer patients.
Details
- Title: Subtitle
- 88. Psychological resilience is associated with markers of inflammation and angiogenesis in pre-surgical ovarian cancer patients
- Creators
- L Zagorski - Department of Psychology, The University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, United StatesK DeGeest - Department of Obstetrics & Gynecology, University of Iowa, United StatesP.H Thaker - Division of Gynecologic Oncology; Department of Obstetrics and Gynecology, Washington University School of Medicine, United StatesG.M Slavich - Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, United StatesF Penedo - Department of Psychology and Sylvester Comprehensive Cancer Center, University of Miami, United StatesS Cole - Division of Hematology–Oncology, UCLA School of Medicine, The Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA Molecular Biology Institute, University of California at Los Angeles, United StatesA.K Sood - Departments of Gynecologic Oncology and Cancer Biology, M.D. Anderson Cancer Center, United StatesD Lubaroff - Department of Urology, Holden Comprehensive Cancer Center, University of Iowa, United StatesS Lutgendorf - Department of Psychology, The University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, United States
- Resource Type
- Abstract
- Publication Details
- Brain, behavior, and immunity, Vol.26, pp.S25-S25
- DOI
- 10.1016/j.bbi.2012.07.112
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065769002771
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