Impaired regeneration: A role for the muscle microenvironment in cancer cachexia

Erin E Talbert; Denis C Guttridge

doi:10.1016/j.semcdb.2015.09.009

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Impaired regeneration: A role for the muscle microenvironment in cancer cachexia

Journal article

Peer reviewed

Impaired regeneration: A role for the muscle microenvironment in cancer cachexia

Erin E Talbert and Denis C Guttridge

Seminars in cell & developmental biology, Vol.54, pp.82-91

06/2016

DOI: 10.1016/j.semcdb.2015.09.009

PMCID: PMC4922677

PMID: 26385617

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https://www.ncbi.nlm.nih.gov/pmc/articles/4922677View

Open Access

Abstract

While changes in muscle protein synthesis and degradation have long been known to contribute to muscle wasting, a body of literature has arisen which suggests that regulation of the satellite cell and its ensuing regenerative program are impaired in atrophied muscle. Lessons learned from cancer cachexia suggest that this regulation is simply not a consequence, but a contributing factor to the wasting process. In addition to satellite cells, evidence from mouse models of cancer cachexia also suggests that non-satellite progenitor cells from the muscle microenvironment are also involved. This chapter in the series reviews the evidence of dysfunctional muscle repair in multiple wasting conditions. Potential mechanisms for this dysfunctional regeneration are discussed, particularly in the context of cancer cachexia.

Animals

Cachexia - etiology

Cachexia - metabolism

Cachexia - pathology

Humans

Muscle, Skeletal - metabolism

Muscle, Skeletal - pathology

Muscle, Skeletal - physiopathology

Muscular Atrophy - pathology

Muscular Atrophy - physiopathology

Myoblasts - metabolism

Myoblasts - pathology

Neoplasms - complications

Neoplasms - metabolism

Neoplasms - pathology

Regeneration

Details

Title: Subtitle: Impaired regeneration: A role for the muscle microenvironment in cancer cachexia
Creators: Erin E Talbert - The Ohio State University
Denis C Guttridge - The Ohio State University
Resource Type: Journal article
Publication Details: Seminars in cell & developmental biology, Vol.54, pp.82-91
DOI: 10.1016/j.semcdb.2015.09.009
PMID: 26385617
PMCID: PMC4922677
NLM abbreviation: Semin Cell Dev Biol
ISSN: 1084-9521
eISSN: 1096-3634
Grant note: R01 CA180057 / NCI NIH HHS T32 CA090223 / NCI NIH HHS
Language: English
Date published: 06/2016
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984259394002771

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