Journal article
Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial
Journal of dentistry for children, Vol.83(3), pp.152-160
09/01/2016
PMCID: PMC5364522
PMID: 28327266
Abstract
Purpose: To evaluate the efficacy of xylitol-sweetened milk as a caries-preventive strategy.
Methods: In this nine-month prospective proof-of-principle trial, Peruvian schoolchildren were randomized to one of five different milk groups: (1) eight g of xylitol per 200 mL milk once per day; (2) four g of xylitol per 100 mL milk twice per day; (3) eight g of sorbitol per 200 mL milk once per day; (4) four g of sorbitol per 100 mL milk twice per day; or (5) eight g of sucrose per 200 mL milk once per day. The primary outcome was plaque mutans streptococci (MS) at nine months. A secondary outcome was caries incidence. We hypothesized that children in the xylitol groups would have a greater MS decline and lower caries incidence.
Results: One hundred fifty-three children were randomized in the intent-to-treat analyses. Children receiving xylitol had a greater decline in MS than children receiving sucrose (P=0.02) but were not different from children receiving sorbitol (P=0.07). Dental caries incidence for xylitol once per day or twice per day was 5.3 +/- 3.4 and 4.3 +/- 4.0 surfaces, respectively, compared to sorbitol once per day, sorbitol twice per day, or sucrose (4.1 +/- 2.8, 3.7 +/- 4.2, and 3.2 +/- 3.4 surfaces, respectively). There were no differences in caries incidence between xylitol and sucrose (rate ratio [RR] = 1.51; 95 percent confidence interval [CI] = 0.88, 2.59; P=0.13) or between xylitol and sorbitol (RR = 1.28; 95 percent CI = 0.90, 1.83; P=0.16).
Conclusion: Xylitol-sweetened milk significantly reduced mutans streptococci levels compared to sucrose-sweetened milk, but differences in caries incidence were not de-tected.
Details
- Title: Subtitle
- Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial
- Creators
- Donald L. Chi - Univ Washington, Dept Oral Hlth Sci, Seattle, WA 98195 USAGraciela Zegarra - Univ Alas Peruanas, Dept Pediat Dent, Pueblo Libre, PeruElsa C. Vasquez Huerta - Univ Catolica Santa Maria, Dept Pediat Dent, Arequipa, PeruJorge L. Castillo - Univ Washington, Dept Oral Hlth Sci, Seattle, WA 98195 USAPeter Milgrom - Univ Washington, Dept Oral Hlth Sci, Seattle, WA 98195 USAMarilyn C. Roberts - Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USAAilin R. Cabrera-Matta - Univ Peruana Cayetano Heredia, Dept Stomatol Children & Adolescents, Lima, PeruLloyd Mancl - Univ Washington, Dept Oral Hlth Sci, Seattle, WA 98195 USAAna P. Merino - Univ Peruana Cayetano Heredia, Dept Stomatol Children & Adolescents, Lima, Peru
- Resource Type
- Journal article
- Publication Details
- Journal of dentistry for children, Vol.83(3), pp.152-160
- Publisher
- AMER SOC DENTISTRY CHILD
- PMID
- 28327266
- PMCID
- PMC5364522
- ISSN
- 0022-0353
- eISSN
- 1935-5068
- Number of pages
- 9
- Grant note
- International Association of Dental Research (IADR) Colgate Community-Based Research Award for Caries Prevention Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford University K08DE 020856 / U.S. National Institute of Dental and Craniofacial Research (NIDCR); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) William T. Grant Foundation Scholars Program K08DE020856 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
- Language
- English
- Date published
- 09/01/2016
- Academic Unit
- Public Policy Center (Archive)
- Record Identifier
- 9984283703102771
Metrics
19 Record Views