Journal article
Combination chemotherapy of cisplatin and 5-fluorouracil for advanced colorectal adenocarcinoma
Cancer chemotherapy and pharmacology, Vol.23(1), pp.57-60
01/1989
DOI: 10.1007/BF00258460
PMID: 2909290
Abstract
A total of 24 patients with advanced colorectal adenocarcinoma were entered into a phase I-II study of 5-fluorouracil (5-FU) and cisplatin, 21 of whom had previously received 5-FU. The starting dose of cisplatin was 20 mg/m2 diluted in 1000 cc normal saline, given over 20 h daily for 5 days, together with 600 mg/m2 5-FU diluted in 1000cc fluid, given simultaneously over 20 h daily for 5 days. This regiment was given every 4 weeks. The dose-limiting toxicity was renal and cumulative. All 24 patients were evaluable for toxicity. Of 12 patients on the abovementioned starting dose, 8 underwent a cisplatin dose reduction to 15 mg/m2 due to a progressive decrease in creatinine clearance following the second or third course of treatment. Of 12 patients who started cisplatin at 15 mg/m2 and 5-FU at 600 mg/m2, 11 were maintained at this dose. A WBC nadir count of<2000/mm3 was seen in four patients. Thrombocytopenia occurred in three patients who received 15 mg/m2 cisplatin and 600 mg/m2 5-FU. In all, 21 of the 24 patients had objectively measurable disease and were also evaluable for response as follows: 1 complete response, 2 partial responses, 1 case of stable disease, and 17 patients with progressive disease. © 1989 Springer-Verlag.
Details
- Title: Subtitle
- Combination chemotherapy of cisplatin and 5-fluorouracil for advanced colorectal adenocarcinoma
- Creators
- NicholasJ PetrelliStephan Madejewicz - Roswell Park Cancer InstituteYoucef Rustum - Roswell Park Cancer InstituteLemuel Herrera - Roswell Park Cancer InstitutePatrickJ CreavenJohn Plager - Roswell Park Cancer InstituteJoan Soloman - Roswell Park Cancer InstituteArnold Mittelman - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Cancer chemotherapy and pharmacology, Vol.23(1), pp.57-60
- DOI
- 10.1007/BF00258460
- PMID
- 2909290
- ISSN
- 0344-5704
- eISSN
- 1432-0843
- Language
- English
- Date published
- 01/1989
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360050702771
Metrics
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