Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods

Ellen E Roling; Michael E Klepser; Ashley Wasson; Russell E Lewis; Erika J Ernst; Michael A Pfaller

doi:10.1016/S0732-8893(02)00361-9

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Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods

Journal article

Peer reviewed

Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods

Ellen E Roling, Michael E Klepser, Ashley Wasson, Russell E Lewis, Erika J Ernst and Michael A Pfaller

Diagnostic microbiology and infectious disease, Vol.43(1), pp.13-17

05/2002

DOI: 10.1016/S0732-8893(02)00361-9

PMID: 12052624

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Abstract

The activities of the echinocandins caspofungin and anidulafungin were evaluated alone and in combination with fluconazole using time-kill methods against isolates of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Cryptococcus neoformans. Antifungal concentrations tested against each isolate were 0.5 microg/mL and 20 microg/mL of fluconazole and 0.007 microg/mL and 2 microg/mL of both caspofungin and anidulafungin. In addition, 20 microg/mL of fluconazole was tested with 2 microg/mL of caspofungin and anidulafungin to test for additive or antagonistic activity. Finally 0.5 microg/mL of fluconazole was tested with 0.007 microg/mL of caspofungin and anidulafungin to test for synergy. Combinations of fluconazole and caspofungin or anidulafungin resulted in indifference. Azole-echinocandin combinations do not produce antagonistic effects; therefore, combinations of these agents may warrant future clinical evaluation.

Anidulafungin

Anti-Bacterial Agents - pharmacology

Antifungal Agents - pharmacology

Candida - drug effects

Caspofungin

Cell Division - drug effects

Cryptococcus neoformans - drug effects

Drug Resistance, Multiple, Fungal

Drug Therapy, Combination

Echinocandins

Fluconazole - pharmacology

Humans

Lipopeptides

Logistic Models

Microbial Sensitivity Tests

Peptides

Peptides, Cyclic - pharmacology

Time Factors

Details

Title: Subtitle: Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods
Creators: Ellen E Roling - University of Iowa
Michael E Klepser - Ferris State University
Ashley Wasson - University of Iowa
Russell E Lewis - University of Iowa
Erika J Ernst - University of Iowa
Michael A Pfaller - University of Iowa
Resource Type: Journal article
Publication Details: Diagnostic microbiology and infectious disease, Vol.43(1), pp.13-17
DOI: 10.1016/S0732-8893(02)00361-9
PMID: 12052624
ISSN: 0732-8893
eISSN: 1879-0070
Language: English
Date published: 05/2002
Academic Unit: Epidemiology; Pathology; Pharmacy Practice and Science
Record Identifier: 9984365888302771

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