Dataset
Dataset for Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-null and CYP2A6-Humanized Mice
University of Iowa
06/21/2023
DOI: 10.25820/data.006613
Abstract
This dataset summarized a study of investigating the distribution of 2,2’,3,5,5’-pentachlorinated biphenyl (PCB 95) and its hydroxylated metabolites (as methoxylated derivatives) in the wild type (WT), Cyp2abfgs-null (KO) and CYP2A6-Humanized (KI) mice that were exposed to racemic PCB 95 (1 mg/kg bw) with stripped corn oil as vehicle by single gavage dosing. The dataset contains mass (ng) and concentration (ng/g tissue) of PCB 95 and its metabolites in adipose, blood, brain and liver, the tissue weight of tissues used for the analysis, enantiomeric fraction values of PCB 95 in the different tissues, and the QA/QC data.
Details
- Title: Subtitle
- Dataset for Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-null and CYP2A6-Humanized Mice
- Creators
- Xueshu Li - University of Iowa, Occupational and Environmental HealthAmanda J BullertWeiguo Han - University of ArizonaWeizhu Yang - University of ArizonaQing-Yu Zhang - University of ArizonaXinxin Ding - University of ArizonaHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.006613
- Publisher
- University of Iowa
- Grants
- Grant note
- This work was supported by grants R01 ES014901, R21 ES027169, and R01 ES031098 from the National Institute of Environmental Health Sciences, National Institutes of Health. The Environmental Health Sciences Research Center (P30 ES005605) and the Iowa Superfund Research Program (P43 ES013661) supported the authentication of the test compounds and the analytical work. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences or the National Institutes of Health.
- Language
- English
- Date collected
- 09/06/2019–12/02/2019
- Date published
- 06/21/2023
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984424831102771
Metrics
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