Neighborhood Deprivation and Neural Tube Defects

Shannon Pruitt Evans; Elizabeth C. Ailes; Michael R. Kramer; Charles J. Shumate; Jennita Reefhuis; Tabassum Z. Insaf; Mahsa M. Yazdy; Suzan L. Carmichael; Paul A. Romitti; Marcia L. Feldkamp; Dayna T. Neo; Wendy N. Nembhard; Gary M. Shaw; Elizabeth Palmi; Suzanne M. Gilboa; National Birth Defects Prevention Study

doi:10.1097/EDE.0000000000001655

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Neighborhood Deprivation and Neural Tube Defects

Journal article

Peer reviewed

Neighborhood Deprivation and Neural Tube Defects

Shannon Pruitt Evans, Elizabeth C. Ailes, Michael R. Kramer, Charles J. Shumate, Jennita Reefhuis, Tabassum Z. Insaf, Mahsa M. Yazdy, Suzan L. Carmichael, Paul A. Romitti, Marcia L. Feldkamp, …

Epidemiology (Cambridge, Mass.), Vol.34(6), pp.774-785

11/2023

DOI: 10.1097/EDE.0000000000001655

PMCID: PMC10928547

PMID: 37757869

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10928547/pdf/nihms-1967854.pdfView

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Abstract

Background: Individual measures of socioeconomic status (SES) have been associated with an increased risk of neural tube defects (NTDs); however, the association between neighborhood SES and NTD risk is unknown. Using data from the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we investigated the association between measures of census tract SES and NTD risk. Methods: The study population included 10,028 controls and 1829 NTD cases. We linked maternal addresses to census tract SES measures and used these measures to calculate the neighborhood deprivation index. We used generalized estimating equations to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) estimating the impact of quartiles of census tract deprivation on NTDs adjusting for maternal race–ethnicity, maternal education, and maternal age at delivery. Results: Quartiles of higher neighborhood deprivation were associated with NTDs when compared with the least deprived quartile (Q2: aOR = 1.2; 95% CI = 1.0, 1.4; Q3: aOR = 1.3, 95% CI = 1.1, 1.5; Q4 (highest): aOR = 1.2; 95% CI = 1.0, 1.4). Results for spina bifida were similar; however, estimates for anencephaly and encephalocele were attenuated. Associations differed by maternal race–ethnicity. Conclusions: Our findings suggest that residing in a census tract with more socioeconomic deprivation is associated with an increased risk for NTDs, specifically spina bifida.

Details

Title: Subtitle: Neighborhood Deprivation and Neural Tube Defects
Creators: Shannon Pruitt Evans - National Center on Birth Defects and Developmental Disabilities
Elizabeth C. Ailes - National Center on Birth Defects and Developmental Disabilities
Michael R. Kramer - Emory University
Charles J. Shumate - Texas Department of State Health Services
Jennita Reefhuis - Centers for Disease Control and Prevention
Tabassum Z. Insaf - New York State Department of Health
Mahsa M. Yazdy - Massachusetts Department of Public Health
Suzan L. Carmichael - Stanford University
Paul A. Romitti - University of Iowa
Marcia L. Feldkamp - University of Utah
Dayna T. Neo - University of North Carolina at Chapel Hill
Wendy N. Nembhard - University of Arkansas for Medical Sciences
Gary M. Shaw - Stanford University
Elizabeth Palmi - National Center on Birth Defects and Developmental Disabilities
Suzanne M. Gilboa - National Center on Birth Defects and Developmental Disabilities
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Epidemiology (Cambridge, Mass.), Vol.34(6), pp.774-785
DOI: 10.1097/EDE.0000000000001655
PMID: 37757869
PMCID: PMC10928547
NLM abbreviation: Epidemiology
ISSN: 1044-3983
eISSN: 1531-5487
Language: English
Date published: 11/2023
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984473941502771

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