Abstract
0090 Impact of Evening Binge Alcohol Consumption on Nocturnal Heart Rate Response to Cortical Arousal
Sleep (New York, N.Y.), Vol.47(Supplement_1), pp.A40-A40
05/01/2024
DOI: 10.1093/sleep/zsae067.0090
Abstract
Introduction Chronic alcohol consumption increases the risk of cardiovascular disease. While acute alcohol intake increases heart rate (HR), the impact of alcohol on HR responses to nocturnal arousals remains unclear. The present study investigated the effect of evening binge alcohol consumption on HR responsiveness to nocturnal cortical arousals. We hypothesized that alcohol intake would lead to an exaggerated HR reactivity to cortical arousals throughout the sleep period. Methods Fifteen healthy adults (6 male, 9 female; 27±2 yrs; 28±1 kg/m²) participated in this study. Using a randomized cross-over design, participants underwent two testing conditions (i.e., alcohol vs fluid control) separated by one month. In the alcohol condition, participants consumed the equivalent of 4-5 drinks in the span of two hours prior to sleep. A volume matched fluid-control was utilized for the control condition. The alcohol dose was based on the NIAAA definition of binge drinking (i.e., 1g/kg men, 0.85 g/kg women). Overnight polysomnography (PSG) with continuous electrocardiogram (ECG) was utilized over the course of an 8-hour in laboratory sleep period to quantify sleep, arousals, and nocturnal HR. Arousals were only included if they were not associated with any respiratory events, limb movements, or awakenings. HR responses following spontaneous nocturnal cortical arousals were collected and analyzed across 20 cardiac cycles. Results A main effect of experimental condition was observed whereby alcohol consumption resulted in a significantly elevated heart rate (Fluid Control: 64±2 vs. Alcohol: 72±3 beats/min, p< 0.001). There was no main effect of condition on HR reactivity (Placebo: ∆1.7±1, Alcohol: ∆2.1±1 beats/min, p=0.545). A significant condition x time effect was observed when assessing both raw HR (p=0.005) and HR reactivity (p=0.005). In contrast to our initial hypothesis, HR reactivity during the early phase of the arousal response was reduced in the alcohol condition at cardiac cycles 2, 3, and 4 (all p< 0.05) following nocturnal arousal occurrence. Conclusion These findings indicate that evening alcohol intake increases nocturnal HR, leading to a blunted HR response to cortical arousals. The sustained effect of alcohol on nocturnal HR may contribute to cardiovascular risks associated with evening binge alcohol consumption. Support (if any) Funding: NIH (AA-024892; U54GM115371; P20GM103474).
Details
- Title: Subtitle
- 0090 Impact of Evening Binge Alcohol Consumption on Nocturnal Heart Rate Response to Cortical Arousal
- Creators
- Ankita Talukdar - Baylor UniversityTatiana Solis-Montenegro - Baylor UniversityJenna-Marie Beisert - Baylor UniversityJennifer Bigalke - Baylor UniversityJeremy Bigalke - Baylor UniversityJason Carter - Baylor University
- Resource Type
- Abstract
- Publication Details
- Sleep (New York, N.Y.), Vol.47(Supplement_1), pp.A40-A40
- DOI
- 10.1093/sleep/zsae067.0090
- ISSN
- 1550-9109
- eISSN
- 1550-9109
- Publisher
- Oxford University Press
- Grant note
- NIH: AA-024892, U54GM115371, P20GM103474
Funding: NIH (AA-024892; U54GM115371; P20GM103474).
- Language
- English
- Date published
- 05/01/2024
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9985222718102771
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