Abstract
0207 NREM Sleep Oscillations and Their Relations to Mood Symptoms in Children with Anxiety Disorders
Sleep (New York, N.Y.), Vol.47(Supplement_1), pp.A89-A89
04/20/2024
DOI: 10.1093/sleep/zsae067.0207
Abstract
Abstract Introduction Sleep disturbances are common in children and adolescents with anxiety disorders. NREM sleep oscillations have been associated with affect and emotional wellbeing and undergo drastic maturational changes during puberty. The primary objective of the current study was to quantify NREM microstructure in children with anxiety disorders (Generalized Anxiety Disorder, Separation Anxiety Disorder or Social Anxiety Disorder) and examine their relations with severity of mood symptoms. Methods Forty-two participants (9-13 years, mean age: 11.33 years, n(anxiety)=16, n(comparison)=26) completed an in-lab overnight polysomnography session (with a 32-channel EEG acquisition device). Sleep spindles and slow oscillations during N2 and N3 sleep were detected with a validated wavelet-based algorithm and characterized using custom scripts. Symptom severity was measured based on parent reports on Child Behavior Checklist (CBCL) and Revised Children's Anxiety and Depression Scale (RCADS). Regressions between symptoms and NREM oscillation characteristics were based on 3 representative electrodes (Cz, Fz, Pz) Results Spindle duration was significantly reduced in children with anxiety (7 electrodes, tsum = -17.04, pcorrected = 0.04). In the entire sample, spindle duration was associated with severity of depression such that shorter spindle duration correlated significantly with higher depressive symptoms (frontal: p <.001, central: p =.03, parietal: p =.02). We didn’t observe any other differences in NREM oscillation characteristics. There were no group differences in sleep duration, quality or architecture. Conclusion In a sample of mostly prepubertal children with anxiety disorders, we observed a reduction in spindle duration compared to a demographically matched group of typically developing children. This finding was in the context of normal sleep duration, quality and architecture. Reduced spindle duration was associated with heightened depressive symptoms. Spindle duration has been associated with general cognitive ability and has been shown to decrease linearly with age during adolescence. A recent study on older adolescents at clinical high risk for psychotic disorders also reveals a significant reduction in spindle duration. These findings suggest that alterations in spindle duration may be a marker of general psychopathology in adolescence. Our future plans include repeating sleep monitoring longitudinally in these participants to trace the developmental trajectory of NREM oscillations across different stages of puberty. Support (if any) Iowa Neuroscience Institute Pilot Grant (Ideas Lab)
Details
- Title: Subtitle
- 0207 NREM Sleep Oscillations and Their Relations to Mood Symptoms in Children with Anxiety Disorders
- Creators
- Hazal ArpaciAditi Tripathy - University of Iowa, Internal MedicineIntisar Becic - University of IowaAnna Holowicki - University of IowaNarges Firouzshahi - University of IowaMorgan LottAvery MaederBengi Baran - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Sleep (New York, N.Y.), Vol.47(Supplement_1), pp.A89-A89
- DOI
- 10.1093/sleep/zsae067.0207
- ISSN
- 0161-8105
- eISSN
- 1550-9109
- Language
- English
- Date published
- 04/20/2024
- Academic Unit
- Iowa Neuroscience Institute; Psychiatry; Psychological and Brain Sciences; Internal Medicine
- Record Identifier
- 9984649059102771
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