Abstract
0915 The Effects of Eszopiclone on Spindles, Slow Oscillations and their Coordination in Health and Schizophrenia
Sleep (New York, N.Y.), Vol.42(Supplement_1), pp.A367-A368
04/13/2019
DOI: 10.1093/sleep/zsz067.913
Abstract
Introduction
Patients with schizophrenia have sleep spindle deficits that correlate with impaired sleep-dependent memory consolidation. In a previous study of schizophrenia, eszopiclone, a non-benzodiazepine sedative hypnotic, despite increasing spindles, failed to improve memory. Here, we investigated whether this failure reflected that eszopiclone disrupts slow oscillations (SOs) and their coordination with spindles, both of which are critical for memory consolidation.
Methods
Twenty-six chronic, medicated patients with schizophrenia (32±8yrs, 21 male) and 29 demographically matched healthy controls participated in a double-blind, placebo-controlled, cross-over study. Placebo and eszopiclone visits both involved polysomnography on two consecutive nights. On the second night of each visit, participants trained on the finger tapping motor sequence task (MST) and were tested the following morning. We evaluated eszopiclone effects on SOs (0.5-4Hz), spindles (12-15Hz), SO phase at spindle peak (timing) and the variability of this timing (consistency) during stage 2 non-rapid eye movement sleep and how they related to overnight improvement of MST performance.
Results
Regardless of group and condition (eszopiclone, placebo), SO-spindle coordination, both timing and consistency, were stable across nights. While timing did not differ between groups, patients unexpectedly were more consistent (pcorrected=.01). Eszopiclone affected both groups similarly: it increased spindle density (pcorrected<.001), reduced the consistency of SO-spindle timing (pcorrected<.001) and reduced SO amplitude (pcorrected<.001). Eszopiclone did not improve memory (p=.16). At the placebo visit, spindle density correlated with overnight MST improvement (pcorrected=.05). At the eszopiclone visit, SO amplitude, but not spindle density (pcorrected=.19), predicted overnight MST improvement and only in schizophrenia (Amplitude by Group interaction pcorrected=.04; Schizophrenia, r=.44, p=.03).
Conclusion
Eszopiclone changed the morphology of SOs, made their timing in relation to spindles less consistent and not only did not improve memory, but disrupted the correlation between overnight improvement’s and spindle density. This suggests that interventions to improve memory need not only to increase spindle density but also to preserve or enhance both SOs and their coordination with spindles.
Details
- Title: Subtitle
- 0915 The Effects of Eszopiclone on Spindles, Slow Oscillations and their Coordination in Health and Schizophrenia
- Creators
- Dimitris Mylonas - Harvard Medical School, Boston, MA, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USACharmaine Demanuele - Harvard Medical School, Boston, MA, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USABengi Baran - Harvard Medical School, Boston, MA, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USARoy Cox - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USARobert Stickgold - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USADara S Manoach - Harvard Medical School, Boston, MA, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA
- Resource Type
- Abstract
- Publication Details
- Sleep (New York, N.Y.), Vol.42(Supplement_1), pp.A367-A368
- DOI
- 10.1093/sleep/zsz067.913
- ISSN
- 0161-8105
- eISSN
- 1550-9109
- Language
- English
- Date published
- 04/13/2019
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984071667102771
Metrics
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