0982 Associations Between Bedroom Dust Allergen Exposures and Sleep Symptoms in School-Age Children

Seyni Gueye-Ndiaye; Youmeng Wang; Jing Wang; Cecilia Castro-Diehl; Michael Rueschman; Tamar Sofer; Peggy Lai; Judith Owens; Diane R Gold; Gary Adamkiewicz; Nervana Metwali; Peter Thorne; Wanda Phipatanakul; Susan Redline

doi:10.1093/sleep/zsaf090.0982

Back

0982 Associations Between Bedroom Dust Allergen Exposures and Sleep Symptoms in School-Age Children

Abstract

Open access

Peer reviewed

0982 Associations Between Bedroom Dust Allergen Exposures and Sleep Symptoms in School-Age Children

Seyni Gueye-Ndiaye, Youmeng Wang, Jing Wang, Cecilia Castro-Diehl, Michael Rueschman, Tamar Sofer, Peggy Lai, Judith Owens, Diane R Gold, Gary Adamkiewicz, …

Sleep (New York, N.Y.), Vol.48(Supplement_1), pp.A425-A426

05/19/2025

DOI: 10.1093/sleep/zsaf090.0982

Files and links (1)

url

https://doi.org/10.1093/sleep/zsaf090.0982View

Published (Version of record) Open Access

Abstract

Exposure to allergens has been shown to trigger inflammatory pathways contributing to sleep-disordered breathing (SBD) and fragmented sleep, specifically in children with atopic diseases. However, little is known about the relationship between indoor allergen exposure and sleep symptoms in children in the general population, or how several inflammatory-related health factors, such as asthma, allergic rhinitis, or obesity, contribute to this relationship. We investigated the associations between high indoor allergen concentrations, sleep quality dimensions, and SDB in children ages 6-12 years old living in predominantly low-income neighborhoods. Methods Bedroom dust aeroallergens were collected in participants’ bedrooms. Outcomes were caregiver-reported sleep-related daytime impairment and sleep disturbance (pediatric PROMIS instruments), symptoms of SDB (AHI/ODI), and actigraphy based short sleep (< 8 hours) duration and poor sleep continuity (sleep fragmentation > 75th percentile). Logistic regression was used to examine associations between aeroallergens and sleep disturbances, adjusting age, sex, race, ethnicity, maternal education. Results The sample included 256 children (age 9.5 years; 41% Hispanic, 29% Black, 22% White, 8% Other; 43% female) with 27% reported maternal education attainment of a high school or less. 38% lived in disadvantaged neighborhoods (neighborhood Child Opportunity Index < 40). Mouse (Musm1), cat (Feld1), and dog (Canf1) allergens were detected in 81%, 72%, and 53% of households, respectively. Elevated mouse allergen exposure (>0.55 μg/g-75th percentile) was associated with a 2.6-fold (95%CI:1.34, 5.03) increased adjusted odds for sleep-related daytime impairment (PROMIS T-score > 55). This association persisted after adjustment for health factors (asthma, allergic rhinitis, obesity, and environmental tobacco smoke exposure), neighborhood disadvantage, and SDB. There was attenuation of this association with poor sleep consolidation and frequent awakenings. There were no associations with the other sleep outcomes or exposures. Conclusion Our results reveal that elevated mouse exposure was associated with increased sleep-related daytime impairment symptoms in children living in predominantly low-income neighborhoods. The mechanisms that link this association are not clear, however poor sleep quality explained some of this relationship. Strategies to reduce household exposure and improve air quality should be tested as approaches for reducing health disparities.

Details

Title: Subtitle: 0982 Associations Between Bedroom Dust Allergen Exposures and Sleep Symptoms in School-Age Children
Creators: Seyni Gueye-Ndiaye - Boston Children's Hospital
Youmeng Wang - Brigham and Women's Hospital
Jing Wang - Brigham and Women's Hospital
Cecilia Castro-Diehl - Brigham and Women's Hospital
Michael Rueschman - Brigham and Women's Hospital
Tamar Sofer - Beth Israel Deaconess Medical Center
Peggy Lai - Massachusetts General Hospital
Judith Owens - Boston Children's Hospital
Diane R Gold - Harvard University
Gary Adamkiewicz
Nervana Metwali - University of Iowa
Peter Thorne - University of Iowa, Occupational and Environmental Health
Wanda Phipatanakul - Boston Children's Hospital
Susan Redline - Brigham and Women's Hospital
Resource Type: Abstract
Publication Details: Sleep (New York, N.Y.), Vol.48(Supplement_1), pp.A425-A426
Publisher: Oxford Academic; CARY
DOI: 10.1093/sleep/zsaf090.0982
ISSN: 0161-8105
eISSN: 1550-9109
Grant note: National Institutes of Health: R01HL137192, U01AI110397, K24AI106822, P30ES000002, R35HL135818
National Institutes of Health (R01HL137192), (U01AI110397, K24AI106822 [to Phipatanakul]), (P30ES000002 [to Gold]), and (R35HL135818 [to Redline]).
Language: English
Date published: 05/19/2025
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health
Record Identifier: 9984824329202771

Metrics

1 Record Views