Abstract
1125 COMPARISON OF SPINDLE DENSITY AND PROCEDURAL MEMORY RELIABILITY IN NAP AND OVERNIGHT SLEEP
Sleep (New York, N.Y.), Vol.40(suppl_1), pp.A419-A419
04/28/2017
DOI: 10.1093/sleepj/zsx050.1124
Abstract
Abstract
Introduction:
Sleep spindle density has shown good test-retest reliability in nocturnal sleep and in naps. Additionally, both nocturnal sleep and naps enhance memory consolidation. However, research on the reliability of spindle density and memory enhancement between nocturnal sleep and naps is lacking. If naps provide reliable estimates of nocturnal sleep spindle density and overnight memory consolidation, future studies of spindles and sleep-dependent memory consolidation can be tested using naps rather than more expensive and time-consuming overnight studies.
Methods:
15 patients with schizophrenia (23–43 yrs, M = 32.5, SD = 6.23) and 8 healthy controls (23–42 yrs, M = 31.4, SD = 6.11) trained on the finger tapping motor sequence task (MST) in the evening and were tested after nocturnal sleep. Months later, the participants learned the MST with a different sequence in the afternoon and were tested after a 90-minute nap opportunity. Both overnight and nap sleep were monitored with polysomnography. Spindle density during N2 was measured using the WaveCount spindle detector. Overnight/overnap MST improvement was calculated as the percent increase in correct sequences from the last 3 training trials to the first 3 test trials the following night or nap.
Results:
Preliminary results indicate a weak intraclass correlation for MST improvement in the overnight versus nap conditions (r= 0.26, p = 0.099) with n=23. Spindle density for all 23 participants has yet to be calculated; spindle density reliability between conditions will be assessed once records are scored.
Conclusion:
Our preliminary investigation indicates weak reliability of MST improvement overnight and over-nap. We will next examine spindle density to determine whether naps can substitute for nocturnal sleep in studies of this type. We will also determine whether schizophrenia patients show different reliability for memory consolidation and spindle density than controls. While we assume that spindle density is a trait, we will assess the effects of the time interval between the night and the nap on reliability.
Support (If Any):
This project was supported by NIH 1-K24-MH099421-01 and 1R01MH092638-01A1.
Details
- Title: Subtitle
- 1125 COMPARISON OF SPINDLE DENSITY AND PROCEDURAL MEMORY RELIABILITY IN NAP AND OVERNIGHT SLEEP
- Creators
- C Tocci - 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MAE Kohnke - 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MAD Mylonas - 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MAB Baran - 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MAE Parr - 2 Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MAR Stickgold - 2 Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MAD S Manoach - 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MA
- Resource Type
- Abstract
- Publication Details
- Sleep (New York, N.Y.), Vol.40(suppl_1), pp.A419-A419
- DOI
- 10.1093/sleepj/zsx050.1124
- ISSN
- 0161-8105
- eISSN
- 1550-9109
- Publisher
- Oxford University Press; US
- Alternative title
- 31st Annual Meeting of the Associated Professional Sleep Societies, LLC
- Language
- English
- Date published
- 04/28/2017
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984071664902771
Metrics
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