Abstract
1375: IMPACT OF SEPTICEMIA ON OUTCOMES IN HOSPITALIZED ADULT HEART TRANSPLANT RECIPIENTS
Critical care medicine, Vol.44(12), pp.419-419
12/2016
DOI: 10.1097/01.ccm.0000510049.61866.fe
Abstract
Learning Objectives: Cardiac transplantation is the treatment of choice for many patients with end-stage heart failure refractory to medical treatment. Infections are a major cause of morbidity and mortality in heart transplant recipients. Current national estimates of impact of septicemia in heart transplant recipients are unclear. We sought to estimate the prevalence of septicemia in hospitalized heart transplant recipients and to assess the outcomes, specifically in-hospital mortality (IHM), hospital charges (HC) and length of stay(LOS), in heart transplant recipients with septicemia.
Methods: We performed a retrospective analysis of the Nationwide Inpatient Sample, the largest all-payer inpatient care database in the United States, for the years 2012 and 2013. All patients aged >18 years who had a heart transplantation were included. Outcomes included IHM, LOS and HC. Primary independent variable was occurrence of septicemia. Multivariable logistic (for IHM) and linear regression models (for HC and LOS) were used to examine the association between occurrence of septicemia and outcomes.
Results: 4245 patients had a heart transplantation. The mean age was 53 years. 70% were males. Whites comprised 66% of patients. Primary payers included Medicare (38.8%), Medicaid (11.5%), and private insurance (46.6%). 820 patients (19.3%) developed septicemia. IHM rate in those who developed septicemia was 17.7% (compared to 2.2% in those without septicemia). Hospital charges in those with septicemia was $1.18 million (compared to $658,594 in those without septicemia). LOS in those with septicemia was 62.7 days (compared to 31 days in those without septicemia). Following adjustment for patient and hospital level factors, those with septicemia had significantly higher odds for IHM (OR=10.03, 95%CI=5.09–19.76, p<0.01), increased LOS (p<0.01), and higher HC (p<0.01).
Conclusions:Nearly 1 in 5 hospitalized heart transplant recipient developed septicemia. Those who developed septicemia were associated with significantly worse outcomes. Infection control practices must be further optimized in these high risk surgical cohorts.
Details
- Title: Subtitle
- 1375: IMPACT OF SEPTICEMIA ON OUTCOMES IN HOSPITALIZED ADULT HEART TRANSPLANT RECIPIENTS
- Creators
- Veerajalandhar AllareddySankeerth RampaRomesh NalliahMin Kyeong LeeVeerasathpurush AllareddyMarcelo Auslender
- Resource Type
- Abstract
- Publication Details
- Critical care medicine, Vol.44(12), pp.419-419
- DOI
- 10.1097/01.ccm.0000510049.61866.fe
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984657735502771
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