Abstract
138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability
Brain, behavior, and immunity, Vol.26, pp.S38-S38
09/2012
DOI: 10.1016/j.bbi.2012.07.162
Abstract
Introduction: Elevations in the pro-inflammatory cytokine interleukin-6 (IL-6) and alterations in the anti-inflammatory hormone cortisol have been reported in a variety of cancers. IL-6 has prognostic significance in ovarian cancer and cortisol has been associated with fatigue, disability, and vegetative depression in ovarian cancer patients prior to surgery. Despite these relationships, the trajectory of these substances following primary treatment has not been examined. Methods: Ovarian cancer patients undergoing primary treatment completed psychological self-report measures and collected salivary cortisol and plasma IL-6 prior to surgery, at six months, and at one year. Patients included in this study (163 at time of surgery) had completed chemotherapy and had no evidence of disease recurrence. Results: At 6months, patients showed significant reductions in nocturnal cortisol secretion, plasma IL-6, and a more normalized diurnal cortisol rhythm, changes that were maintained at one year. The reductions in IL-6 and nocturnal cortisol were associated with declines in self-reported fatigue, vegetative depression and disability. Conclusions: These findings suggest that primary treatment for ovarian cancer reduces the inflammatory response. Moreover, patients who have not developed recurrent disease by one year appear to maintain more normalized levels of cortisol and IL-6. Improvement in fatigue and vegetative depression is associated with the normalization of IL-6 and cortisol, a pattern which may be relevant for improvements in overall quality of life for ovarian cancer patients.
Details
- Title: Subtitle
- 138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability
- Creators
- A.D Schrepf - University of Iowa, Department of Psychology, E11 Seashore Hall, Iowa City, IA 52242, USAL Clevenger - University of Iowa, Department of Psychology, E11 Seashore Hall, Iowa City, IA 52242, USAD Christensen - University of Iowa, Department of Psychology, E11 Seashore Hall, Iowa City, IA 52242, USAK DeGeest - Department of Obstetrics and Gynecology, University of Iowa, United StatesD Bender - Department of Obstetrics and Gynecology, University of Iowa, United StatesA Ahmed - Department of Obstetrics and Gynecology, University of Iowa, United StatesM Goodheart - Department of Obstetrics and Gynecology, University of Iowa, United StatesL Dahmoush - Department of Pathology, University of Iowa, United StatesF Penedo - Department of Psychology and Sylvester Comprehensive Cancer Center, University of Miami, United StatesJ Lucci - Division of Gynecologic Oncology and Sylvester Comprehensive Cancer Center, University of Miami, United StatesP Ganjei-Azar - Department of Pathology and Sylvester Comprehensive Cancer Center, University of Miami, United StatesL Mendez - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Florida International University School of Medicine, United StatesK Markon - University of Iowa, Department of Psychology, E11 Seashore Hall, Iowa City, IA 52242, USAS Lutgendorf - University of Iowa, Department of Psychology, E11 Seashore Hall, Iowa City, IA 52242, USA
- Resource Type
- Abstract
- Publication Details
- Brain, behavior, and immunity, Vol.26, pp.S38-S38
- DOI
- 10.1016/j.bbi.2012.07.162
- ISSN
- 0889-1591
- eISSN
- 1090-2139
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065886302771
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