1500-P: Global Trends in Mortality and Disability Adjusted Life Years (DALYs) of Type 1 Diabetes Mellitus in Adolescents and Young Adults (15–39y) from 1990 to 2021

Muhammad Haider; Husnain Ahmad; Iffat Magsi; Mian Kakakhel; Umar Hayat; Ishtiaq Ahmad

doi:10.2337/db25-1500-P

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1500-P: Global Trends in Mortality and Disability Adjusted Life Years (DALYs) of Type 1 Diabetes Mellitus in Adolescents and Young Adults (15–39y) from 1990 to 2021

Abstract

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1500-P: Global Trends in Mortality and Disability Adjusted Life Years (DALYs) of Type 1 Diabetes Mellitus in Adolescents and Young Adults (15–39y) from 1990 to 2021

Muhammad Haider, Husnain Ahmad, Iffat Magsi, Mian Kakakhel, Umar Hayat and Ishtiaq Ahmad

Diabetes (New York, N.Y.), Vol.74(Supplement_1), p.1

06/20/2025

DOI: 10.2337/db25-1500-P

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Abstract

Introduction and Objective: Type 1 Diabetes Mellitus (T1DM) poses a substantial global health burden, particularly among adolescents and young adults. This study examines trends in Disability-Adjusted Life Years and mortality associated with T1DM from 1990 to 2021. Methods: Data on DALYs and mortality for individuals aged 15-39 years were collected from Global Burden of Disease study and analyzed using Joinpoint regression models. APC and AAPC were calculated to identify temporal trends. Statistical significance was determined using p-values (<0.05). Results: From 1990 to 2021, T1DM caused a combined 495562 deaths and 40819490 DALYs. DALYs exhibited a slight overall decline (AAPC: -0.0657, 95% CI: -0.098 to -0.028, p = 0.0016), with the most significant reduction from 2000 to 2012 (APC: -0.8420, 95% CI: -0.946 to -0.750, p = 0.0192). However, a slight increase was noted between 2012 and 2021 (APC: 0.2190, 95% CI: 0.091 to 0.375, p = 0.0128). Mortality rates declined more pronouncedly (AAPC: -0.3514, 95% CI: -0.387 to -0.3088, p < 0.000001), with the decrease during 2000-2011 (APC: -1.4747, 95% CI: -1.841 to -1.400, p < 0.000001). Slight increases occurred during 2014-2017 (APC: 0.8121, 95% CI: 0.340 to 1.134, p = 0.0044). Conclusion: While the global burden of T1DM has generally declined, periods of increasing trends highlight the need for sustained public health efforts and research into contributing factors.

Adolescents

Diabetes

Public Health

Diabetes mellitus (insulin dependent)

Mortality

Regression analysis

Trends

Young adults

Details

Title: Subtitle: 1500-P: Global Trends in Mortality and Disability Adjusted Life Years (DALYs) of Type 1 Diabetes Mellitus in Adolescents and Young Adults (15–39y) from 1990 to 2021
Creators: Muhammad Haider
Husnain Ahmad
Iffat Magsi
Mian Kakakhel
Umar Hayat
Ishtiaq Ahmad
Resource Type: Abstract
Publication Details: Diabetes (New York, N.Y.), Vol.74(Supplement_1), p.1
DOI: 10.2337/db25-1500-P
ISSN: 0012-1797
eISSN: 1939-327X
Publisher: American Diabetes Association
Language: English
Date published: 06/20/2025
Academic Unit: Internal Medicine
Record Identifier: 9985088833802771

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