Abstract
1535 RENAL AND VASCULAR RESPONSES TO CONVERTING ENZYME INHIBITION (CEI) DURING FETAL LIFE
Pediatric research, Vol.15, pp.699-699
04/1981
DOI: 10.1203/00006450-198104001-01558
Abstract
The renal and vascular responses to a continuous infusion of captopril (5 μg/min/kg) were studied in 2 groups of chronically catheterized fetal lambs (10 <120 days, 9 >130 days gestation; term 145 days). The infusion of CEI completely blocked the rise in fetal arterial blood pressure (MABP) following a bolus of angiotensin-I (1 μg). In both groups plasma angiotensin-II (A-II) decreased significantly (p<0.05) from 35±16 to 29±11 pg/ml in fetuses <120 days and from 33±5 to 21±3 in fetuses >130 days during CEI. A significant (p<0.05) rise in plasma renin activity (PRA) from 5.9±1.2 to 21.8±7.6 ng/ml/hr was found in fetuses >130 days during CEI; PRA did not increase in fetuses <120 days. The effect of CEI on renal blood flow (RBF), renal vascular resistance (RVR), filtration fraction (FF), glomerular filtration (GFR) and MABP was also studied.
Details
- Title: Subtitle
- 1535 RENAL AND VASCULAR RESPONSES TO CONVERTING ENZYME INHIBITION (CEI) DURING FETAL LIFE
- Creators
- Jean E Robillard - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Pediatric research, Vol.15, pp.699-699
- DOI
- 10.1203/00006450-198104001-01558
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 1
- Language
- English
- Date published
- 04/1981
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Medicine Administration; Stead Family Department of Pediatrics
- Record Identifier
- 9984774212802771
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