Abstract
1536 EFFECT OF ANGIOTENSIN-II BLOCKADE ON GLOMERULAR AND RENAL HEMODYNAMICS DURING FETAL HYPOXEMIA
Pediatric research, Vol.15, pp.699-699
04/1981
DOI: 10.1203/00006450-198104001-01559
Abstract
We previously showed, in fetal lambs >130 days gestation, that fetal hypoxemia produced a significant decrease in renal blood flow (RBF) which is closely related to a rise in plasma renin activity (PRA) (r=-0.77) (Circ Res, in press). The present study was designed to compare changes in glomerular and renal hemodynamics during fetal hypoxemia (HPX) to changes observed when fetal hypoxemia was produced during constant infusion of the converting enzyme inhibitor, captopril (5 μg/min/kg) (HPX-CEI). In both series of experiments (HPX and HPX-CEI) fetal PO2 decreased from 24±2 to 15±1 mmHg and fetal arterial pH remained essentially stable at 7.36±0.01 before and during hypoxemia. Percentage (%) changes in glomerular filtration (GFR), RBF, renal vascular resistance (RVR), filtration fraction (FF), MABP and PRA during HPX in fetuses <120 days and >130 days were compared to % changes observed during HPX-CEI.
Details
- Title: Subtitle
- 1536 EFFECT OF ANGIOTENSIN-II BLOCKADE ON GLOMERULAR AND RENAL HEMODYNAMICS DURING FETAL HYPOXEMIA
- Creators
- J E Robillard - University of IowaR A Gomez - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Pediatric research, Vol.15, pp.699-699
- DOI
- 10.1203/00006450-198104001-01559
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 1
- Language
- English
- Date published
- 04/1981
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Medicine Administration; Stead Family Department of Pediatrics
- Record Identifier
- 9984774211202771
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