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207 THE DYNAMICS OF VASOPRESSIN RESPONSE TO BLOOD VOLUME DEPLETION IN THE LAMB FETUS
Abstract   Peer reviewed

207 THE DYNAMICS OF VASOPRESSIN RESPONSE TO BLOOD VOLUME DEPLETION IN THE LAMB FETUS

Jean E Robillard, Richard E Weitzman and Fred G Smith
Pediatric research, Vol.12, pp.398-398
04/1978
DOI: 10.1203/00006450-197804001-00212

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Abstract

Plasma arginine vasopressin (pAVP) release was measured before and during fetal hemorrhage (H) and 3 hours after fetal blood replacement (T) in 11 chronic fetal lamb preparations (103-138 days gestation). During H there were significant decreases (p<0.05) in fetal hematocrit (34.7±2.5 to 27±1.5%), arterial blood pressure (BP)(58.1±2.5 to 52.2±2.5 mmHg) and fetal pH (7.38±0.01 to 7.35±0.01), but no changes were seen in arterial blood gases (PCO2 − PO2), plasma electrolytes (Na+, K+, C1−) nor osmolality. After T all values returned to baseline levels. Fetal pAVP was measured at various levels of H until ∼30% of the total feto-placental blood volume (T-FPV) was removed. Fetal pAVP increased significantly (p<0.01) in all fetuses from mean basal values of 0.73±0.21 to mean peak values of 34.9±10.04 μU/ml. pAVP was returned to baseline values (1.77±0.67 μU/ml) 3 hours after T. No change in maternal pAVP was seen during H. When fetal pAVP was plotted against the percent of T-FPV removed, the correlation coefficient was 0.65; however, when the log of fetal pAVP was plotted against the percent of T-FPV removed, a correlation coefficient of 0.82 was observed. A multiple regression analysis showed that the decrease in fetal BP was not the primary factor explaining the increase in pAVP during T-FPV depletion. These data show that H is a potent stimulus for fetall pAVP release and suggest that this release is an exponential function of the degree to which T-FPV is depleted.

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