Abstract
221. Area Deprivation Moderates the Relationship Between Polygenic Scores and Mental Health Outcomes
Biological psychiatry (1969), Vol.97(9 Supplement), pp.S186-S186
05/01/2025
DOI: 10.1016/j.biopsych.2025.02.458
Abstract
Background
The Area Deprivation Index (ADI) is a highly confounded variable with both genetic and environmental contributions. Similarly, mental health outcomes are influenced by interactions between genetic and environmental factors. To develop more effective psychiatric treatments, we must understand the relationships and relative contributions of genes and environment to mental health.
Methods
This study examines the complex relationships between ADI, genetic predispositions (here represented by polygenic scores, PGS), and mental health, using the Adult Self Report (ASR), in the SPARK cohort (N=13,034). Since the ADI was correlated with many PGS (e.g., Townsend Index r=0.087, p < 0.005; Educational Attainment r=-0.211, p < 0.005; Depression r=0.101, p < 0.005), we depleted ADI of genetic signal by residualizing it for 148 PGS (ADI-r). After examining linear relationships between ASR and ADI-r, we separated ADI-r into deciles and calculated the Pearson correlations between PGS and ASR subscales within each decile.
Results
The Internalizing ASR score yielded compelling results. As expected, ADI-r is positively correlated with Internalizing (r=0.042, p < 0.005). Interestingly, however, the Depression PGS is more strongly correlated with Internalizing for those in lower ADI-r deciles (e.g., for 1st decile r=0.113, p < 0.005), while it is not significant for higher ADI-r deciles (e.g., for 10th decile r=0.043, p=0.134).
Conclusions
These findings indicate that genetic predispositions for depression have a greater influence in contexts of lower environmental adversity, while higher deprivation may mask genetic effects due to dominant environmental stressors. This highlights the importance of research strategies and clinical interventions that consider both genetic and environmental contexts.
Details
- Title: Subtitle
- 221. Area Deprivation Moderates the Relationship Between Polygenic Scores and Mental Health Outcomes
- Creators
- Ashton Tener - University of IowaJacob Michaelson - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Biological psychiatry (1969), Vol.97(9 Supplement), pp.S186-S186
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.biopsych.2025.02.458
- ISSN
- 0006-3223
- Language
- English
- Date published
- 05/01/2025
- Academic Unit
- Psychiatry; Communication Sciences and Disorders; Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984803713402771
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