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238 The association between quitting electronic cigarette use in pregnancy and the risk of preterm birth and low birth weight
Abstract   Open access   Peer reviewed

238 The association between quitting electronic cigarette use in pregnancy and the risk of preterm birth and low birth weight

Lin Ammar, Hilary A Tindle, Hui Nian, Chang Yu, Brittney M Snyder, Angela M Miller, Kelli Ryckman, Tina V Hartert and Pingsheng Wu
Journal of clinical and translational science, Vol.6(s1), pp.38-38
04/01/2022
DOI: 10.1017/cts.2022.127
PMCID: PMC9209297
url
https://doi.org/10.1017/cts.2022.127View
Published (Version of record) Open Access

Abstract

OBJECTIVES/GOALS: Nearly half of mothers who report electronic (e)-cigarette use during pregnancy believe e-cigarettes are less harmful than traditional cigarettes. We aim to determine the association of quitting e-cigarette use in pregnancy with the risk of preterm birth and low birth weight. METHODS/STUDY POPULATION: We conducted a cross-sectional study of women participating in the Pregnancy Risk Assessment Monitoring System and with live singleton birth during 2016-2019. Women were classified based on their e-cigarette use: before pregnancy only (quitters), last three months of pregnancy only (initiators), at both times (sustained users), and neither time (non-users). We used a modified Poisson regression to determine the association between quitting e-cigarette use and preterm birth (<37 weeks) and low birth weight (<2,500 grams) adjusting for demographic, social-economic, and behavior-related risk factors. Analyses were weighted to account for the survey design and non-response. RESULTS/ANTICIPATED RESULTS: Based on 150,950 women who responded to the survey, there were estimated 2.9% quitters, 0.2% initiators, 1.0% sustained users, and 95.9% non-users in the U.S. Compared to sustained e-cigarette users, quitters had a similar risk in preterm birth (adjusted risk ratio [ARR]: 0.84, 95% confidence interval [CI]: 0.65, 1.08) and a significantly reduced risk in low birth weight (ARR: 0.77, 95%CI: 0.61, 0.97) adjusting for traditional cigarette use, age, race/ethnicity, education, marital status, family income, prior preterm birth, prior live births, BMI prior to pregnancy, pregnancy weight gain, kotelchuck index, multivitamin use, drinking prior to pregnancy, year of birth, and residential state. DISCUSSION/SIGNIFICANCE: As FDA authorizes the sales of certain e-cigarettes, women smokers may switch to e-cigarettes, believing they are reducing harm. Our study shows that quitting e-cigarette use is associated with a reduction of low birth weight. Clear messaging is needed to help women cease e-cigarette use in pregnancy.
 Birth weight Cigarettes Electronic cigarettes Low-birth-weight Population studies Pregnancy Premature birth Risk assessment Risk factors Social behavior

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