Abstract
26-A-13925-ACC VIGOROUS EXERCISE IS ASSOCIATED WITH BETTER QUALITY OF LIFE IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: DATA FROM THE MULTINATIONAL LIFESTYLE AND EXERCISE (LIVE-HCM) STUDY
Journal of the American College of Cardiology, Vol.87(13 Supplement), p.A358
04/2026
DOI: 10.1016/j.jacc.2026.02.887
Abstract
Background
The impact of exercise on quality of life (QOL) in pediatric patients with hypertrophic cardiomyopathy (HCM) is unknown. This study tested if QOL was higher in pediatric HCM patients who exercised vigorously.
Methods
Genotype-positive/phenotypic HCM patients 8-17 yrs old were enrolled at 29 sites from 2015-2022. After excluding 55 phenotype-negative patients, overt HCM patients and parent-proxies reported QOL scores at baseline using the Pediatric Cardiac Quality of Life Inventory (PCQLI) [Total, Disease Impact, and Psychosocial Impact] and the Pediatric Quality of Life Inventory (PedsQL) [Total, Physical Health, and Psychosocial Summary (PSS)]. Exercise intensity was defined as vigorous [≥6 Metabolic Equivalent Task for > 2 mo/yr] or non-vigorous. Covariates included demographic and clinical variables. General Linear Models were used to construct models. Effect size was reported as Partial Eta2 (ɳ2).
Results
There were 82 vigorous/84 non-vigorous exercisers (n=166; age 14±3 yrs). Vigorous exercise had a moderate effect size with higher patient-reported PCQLI Total and Disease Impact, and PedsQL Total, Physical Health, and PSS, and parent-proxy reported PCQLI Disease Impact, and PedsQL Total and PSS scores (Table).
Conclusion
Vigorous exercisers and their parent-proxies reported better physical and psychosocial QOL. These data should inform shared decision-making among providers, parents, and HCM pediatric patients considering vigorous exercise to improve their QOL.
Details
- Title: Subtitle
- 26-A-13925-ACC VIGOROUS EXERCISE IS ASSOCIATED WITH BETTER QUALITY OF LIFE IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: DATA FROM THE MULTINATIONAL LIFESTYLE AND EXERCISE (LIVE-HCM) STUDY
- Creators
- Bradley S. Marino - Cleveland ClinicAmy E. Cassedy - Cleveland ClinicMichael John Ackerman - Cleveland ClinicSharlene M. Day - Cleveland ClinicDominic J. Abrams - Cleveland ClinicBarbara Ainsworth - Cleveland ClinicPeter Aziz - Cleveland ClinicSeshadri Balaji - Cleveland ClinicCharles I. Berul - Cleveland ClinicMartijn Bos - Cleveland ClinicRichard J. Czosek - Cleveland ClinicAnne Marie Dubin - Cleveland ClinicChristopher C. Erickson - Cleveland ClinicSusan P. Etheridge - Cleveland ClinicEugene Kevin Hall - Cleveland ClinicPrince J. Kannankeril - Cleveland ClinicAshwin Lal - Cleveland ClinicIan H. Law - Cleveland ClinicSilvana Molossi - Cleveland ClinicMark W. Russell - Cleveland ClinicElizabeth V. Saarel - Cleveland ClinicLisa Salberg - Cleveland ClinicJonathan Robert Skinner - Cleveland ClinicR. Gregory Webster - Cleveland ClinicRachel J. Lampert - Cleveland Clinic
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.87(13 Supplement), p.A358
- DOI
- 10.1016/j.jacc.2026.02.887
- ISSN
- 0735-1097
- Publisher
- Elsevier
- Language
- English
- Date published
- 04/2026
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9985149568302771
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