Abstract
26-A-14770-ACC VIGOROUS EXERCISE IN CHILDREN WITH HYPERTROPHIC CARDIOMYOPATHY: SUBANALYSIS OF THE PROSPECTIVE, MULTINATIONAL LIFESTYLE AND EXERCISE IN HCM (LIVE-HCM) STUDY
Journal of the American College of Cardiology, Vol.87(13 Supplement), pp.A1238-A1239
04/2026
DOI: 10.1016/j.jacc.2026.02.3050
Abstract
Background
Data suggest that vigorous exercise does not carry excess risk for ventricular arrhythmia (VA) in adults with HCM. Risk in children is not described.
Methods
LIVE-HCM prospectively enrolled patients, age 8-60 years, from 42 sites in 5 countries, 5/2015-2/2019, including 222 children < 18 years. Children and parent-proxies answered physical activity and clinical events surveys every 6 mo for 3 yrs. Vigorous exercise was defined as > 6 METS for >60 hrs/yr. Blinded events committee adjudicated the composite endpoint (sudden death, cardiac arrest, VA treated by ICD, arrhythmic syncope). Only children with overt HCM, N= 167, were analyzed, as no phenotype negative child had an event. A noninferiority hypothesis (boundary of 1.5) between vigorous exercisers and others was tested via multivariable Cox regression analysis
Results
Among the 82 vigorous and 85 non-vigorous exercisers, 14 + 3 years, 61% male, 56% genotype positive, 16 individuals experienced the composite endpoint, 3 in the vigorous and 13 in non-vigorous groups, with rates per 1000 person-yrs for the vigorous of 12 (4-38) and for the non-vigorous 55 (32-94). All HRs met the pre-specified boundary for non-inferiority.
Conclusion
In this overt HCM pediatric cohort, most from expert HCM centers, children exercising vigorously did not experience a higher rate of death or life-threatening VA than the non-vigorous. These data may inform discussion between families and expert providers around exercise participation for children with HCM.
Details
- Title: Subtitle
- 26-A-14770-ACC VIGOROUS EXERCISE IN CHILDREN WITH HYPERTROPHIC CARDIOMYOPATHY: SUBANALYSIS OF THE PROSPECTIVE, MULTINATIONAL LIFESTYLE AND EXERCISE IN HCM (LIVE-HCM) STUDY
- Creators
- Michael John AckermanSharlene M. DayBradley S. MarinoDominic J. AbramsBarbara AinsworthPeter AzizSeshadri BalajiCharles I. BerulMartijn BosRichard J. CzosekAnne Marie DubinChristopher C. EricksonSusan P. EtheridgeEugene Kevin HallPrince J. KannankerilAshwin LalIan H. LawSilvana MolossiMark W. RussellElizabeth V. SaarelLisa SalbergJonathan Robert SkinnerR. Gregory WebsterLIVE HCM ConsortiumRachel J. Lampert
- Resource Type
- Abstract
- Publication Details
- Journal of the American College of Cardiology, Vol.87(13 Supplement), pp.A1238-A1239
- DOI
- 10.1016/j.jacc.2026.02.3050
- ISSN
- 0735-1097
- Publisher
- Elsevier
- Language
- English
- Date published
- 04/2026
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9985149706302771
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