26-A-18081-ACC DOES SCAR MEAN SICKER? LATE GADOLINIUM ENHANCEMENT ON CARDIAC MRI AND RISK OF HEART-FAILURE HOSPITALIZATION IN NON-ISCHEMIC CARDIOMYOPATHY: A META-ANALYSIS

Mubariz Ahmed Hassan; Mohammed Mhanna; Muhammad Adil Afzal; Ola Abdelkarim

doi:10.1016/j.jacc.2026.02.2290

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26-A-18081-ACC DOES SCAR MEAN SICKER? LATE GADOLINIUM ENHANCEMENT ON CARDIAC MRI AND RISK OF HEART-FAILURE HOSPITALIZATION IN NON-ISCHEMIC CARDIOMYOPATHY: A META-ANALYSIS

Abstract

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26-A-18081-ACC DOES SCAR MEAN SICKER? LATE GADOLINIUM ENHANCEMENT ON CARDIAC MRI AND RISK OF HEART-FAILURE HOSPITALIZATION IN NON-ISCHEMIC CARDIOMYOPATHY: A META-ANALYSIS

Mubariz Ahmed Hassan, Mohammed Mhanna, Muhammad Adil Afzal and Ola Abdelkarim

Journal of the American College of Cardiology, Vol.87(13 Supplement), pp.A929-A930

04/07/2026

DOI: 10.1016/j.jacc.2026.02.2290

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Abstract

Background Late gadolinium enhancement (LGE) on cardiac MRI reflects myocardial fibrosis in non-ischemic cardiomyopathy (NICM). Its prognostic significance for heart-failure hospitalization remains uncertain, yet precise risk estimates are critical for guiding discharge planning and follow-up intensity. Methods We conducted a meta-analysis of published non-ischemic cardiomyopathy cohorts that reported heart-failure hospitalization by LGE status on cardiac MRI. Odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled using a random-effects model. Subgroup data were reviewed to explore consistency across patient characteristics. Results Nineteen cohorts including over 3,000 NICM patients were analyzed. LGE was associated with a markedly higher risk of HF hospitalization (pooled OR 3.47, 95% CI 2.43-4.95). In absolute terms, HF hospitalization occurred in ∼20% of LGE negative patients versus ∼55% of LGE positive patients. This association was directionally consistent across sex and ethnicity subgroups, though stratified estimates were rarely reported. Conclusion LGE on cardiac MRI is a robust marker of HF hospitalization risk in NICM, supporting its use in risk stratification and discharge planning.

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Title: Subtitle: 26-A-18081-ACC DOES SCAR MEAN SICKER? LATE GADOLINIUM ENHANCEMENT ON CARDIAC MRI AND RISK OF HEART-FAILURE HOSPITALIZATION IN NON-ISCHEMIC CARDIOMYOPATHY: A META-ANALYSIS
Creators: Mubariz Ahmed Hassan - University of Iowa
Mohammed Mhanna - University of Iowa
Muhammad Adil Afzal - University of Iowa
Ola Abdelkarim - University of Iowa
Resource Type: Abstract
Publication Details: Journal of the American College of Cardiology, Vol.87(13 Supplement), pp.A929-A930
DOI: 10.1016/j.jacc.2026.02.2290
ISSN: 0735-1097
Language: English
Date published: 04/07/2026
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9985148850902771

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