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2.60 Evaluating Physical Health and Comorbid Medical Conditions in Clinical High-Risk for Psychosis Populations: A Multisite Review
Abstract   Open access   Peer reviewed

2.60 Evaluating Physical Health and Comorbid Medical Conditions in Clinical High-Risk for Psychosis Populations: A Multisite Review

Megan Good, Elif Ozan, Stephanie Bousleiman, Tvisha Chatterjea, Halide B. Turkozer, Hyun Jung Kim, Emily E. Carol, Sajel H. Shah, Lauren Utter, Jacqueline Alexandra Clauss, …
Journal of the American Academy of Child and Adolescent Psychiatry, Vol.64(10 Suppl), pp.S212-S212
10/2025
DOI: 10.1016/j.jaac.2025.08.180
url
https://doi.org/10.1016/j.jaac.2025.08.180View
Published (Version of record) Open Access

Abstract

Objectives Medical comorbidities and medical illnesses, which may contribute to psychotic symptoms, have been extensively examined in individuals with psychotic disorders. However, these associations have not been systematically studied in individuals at clinical high-risk for psychosis (CHR-P), who have early or attenuated signs of psychosis and an elevated risk for developing a psychotic disorder. In this study, we reviewed medical diagnoses and clinical evaluation data to characterize the prevalence and patterns of medical conditions in the CHR-P population. Methods We performed a retrospective electronic health record review of 74 CHR-P patients (age 12-30) evaluated at the Massachusetts General Hospital Resilience Evaluation-Social Emotional Training (RE-SET) Program and the McLean Hospital Support, Treatment, and Resilience (STAR) Program from 2018-2025. Medical data, including laboratory results, imaging findings, documented medical comorbidities, physical examination findings, and results of other ancillary diagnostic procedures for each patient were extracted from a period beginning 2 years before and ending 2 years after the patient’s initial CHR-P evaluation. Results The most common medical comorbidities were asthma (12.16%), traumatic brain injury (9.46%), migraine headache (8.11%), obesity (6.76%), and vitamin D deficiency (6.76%). Among patients who underwent noncontrast brain MRI (n = 21), 33.3% (n = 7) had at least one noted abnormality. For patients with abnormal laboratory values, the following was observed: among 38 patients with a lipid panel value, 16 (42.10%) were abnormal, including elevations in total cholesterol (n = 7), triglycerides (n = 6), and low high-density lipoprotein (HDL, n = 4). In individuals with an abnormal CBC (n = 27/41), the eosinophil percentage was elevated (n = 6). BMI was abnormal in 50% of patients (17/34). Among those with abnormal BMI, 13 had a high BMI (>25) and 4 had a low BMI (<18.5). Conclusions Patients who met the criteria for CHR-P had several neurological and medical comorbidities. Future studies should examine how these comorbidities contribute to the emergence or progression of psychosis risk syndromes.

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