Abstract
289 - Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding a biosignature (QUANTIFY): Protocol for a cross-sectional study
The journal of pain, Vol.29(Supplement), 105087
04/2025
DOI: 10.1016/j.jpain.2025.105087
Abstract
Myofascial pain remains an underdiagnosed contributor to musculoskeletal pain conditions, including plantar fasciitis, the most common source of plantar foot pain. The current standard for diagnosing myofascial pain is a clinical exam using manual palpation. Yet this diagnostic standard lacks objective, quantitative thresholds to more precisely assess myofascial pain, highlighting the need for validated biomarkers. This study aims to develop a diagnostic imaging biosignature, which uses both advanced MRI and ultrasound imaging techniques, to detect abnormal myofascial tissue in individuals with plantar fasciitis. The study will also explore if the diagnostic accuracy is enhanced by creating a composite biosignature that includes psychosocial factors. In this cross-sectional study, 100 participants will be recruited, including individuals with plantar fasciitis (n=50), insertional Achilles tendinopathy (n=25), and pain-free controls (n=25). Participants will undergo a clinical exam of 5 muscles in the lower leg and foot to identify sites of abnormal myofascial tissues. Pain intensity will be assessed during walking using the numeric pain rating scale (0 to 10). The primary imaging outcomes will capture the biochemical (T1ρ of muscle and fascia), biomechanical (elastic modulus of the muscle, shear strain of the plantar fascia during passive movement), and structural (fat fraction of the muscle, thickness of the plantar fascia) profile of abnormal myofascial tissue. Secondary outcomes will assess psychological factors (fear of movement, depression, anxiety). This study will provide novel mechanistic insights into myofascial pain through advanced imaging techniques, offering a biopsychosocial framework for better diagnosis and treatment of plantar fasciitis and related conditions.
Details
- Title: Subtitle
- 289 - Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding a biosignature (QUANTIFY): Protocol for a cross-sectional study
- Creators
- Zahra AmerianTimothy FleagleUtsav TuladharBarbara Van GorpJessica DanielsonBrian SmithMichael RichardsMederic HallJim HolmesKathleen SlukaRuth Chimenti
- Resource Type
- Abstract
- Publication Details
- The journal of pain, Vol.29(Supplement), 105087
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2025.105087
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Language
- English
- Date published
- 04/2025
- Academic Unit
- Radiology; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Family and Community Medicine; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984821348102771
Metrics
6 Record Views