Abstract
2997 Venous Thromboembolism Among Hospitalized Patients With Gastric Cancer: Insights From National Inpatient Sample 2004-2014
The American journal of gastroenterology, Vol.114(1), pp.S1622-S1622
10/2019
DOI: 10.14309/01.ajg.0000601520.00865.48
Abstract
INTRODUCTION:
Venous thromboembolism (VTE) is common in patients with malignancies and is associated with significant morbidity and mortality. The occurrence of VTE has been recognized as an independent predictor of mortality in patients with gastric cancer (GC) in smaller studies. However, no nationwide data is available about the VTE-related hospitalizations in patients with GC.
METHODS:
We used the US largest database National Inpatient Sample (NIS) from 2004 to 2014 to identify adults (≥18 yrs) with GC who were hospitalized with VTE using ICD-9 codes. These included patients with both deep vein thrombosis (DVT) and pulmonary embolism (PE) but superficial thrombosis was excluded. We adjusted for baseline demographic characteristics (age, sex, race, insurance, income quartile, history of chemotherapy, Charlson’s comorbidity index) and hospital characteristic (teaching vs. non-teaching, hospital size) to find out the in-hospital outcomes (mortality, length of stay and total hospitalization charges). Regression analysis was used to calculate odds for the association.
RESULTS:
Out of the total 445,719 hospitalizations with GC, 22,658 (5.08%) were identified to be associated with VTE. Out of these, 14,056 were associated with PE and 8602 presented with DVT. There was no significant difference in the mean age or sex. However, patients presenting with VTE were more likely to be and possess private insurance (Table 1). Total inpatient mortalities for these GC patients were 908 in the VTE group vs. 38,096 in the non-VTE (adjusted OR- 0.69, 95% CI 0.59-0.81). On univariate analysis, age, male sex, no history of chemotherapy and Charlson's comorbidity index were associated with increased in-hospital mortality. GC patients admitted with VTE had a significantly lower length of stay (5.6 ± 0.1 days) as compared to GC patients were admitted for other reasons or did not have VTE (6.4 ± 0.03 days) (
P
= 0.000). Similarly, total hospitalization charges were also significantly lower for GC patients with VTE ($38,052 ± 1008 vs. $43,696 ± 583;
P
= 0.001).
CONCLUSION:
In this large inpatient cohort retrospective study on GC patients, hospitalizations with VTE did not confer any change in the rates of mortality. However, length of stay and hospitalization charges were significantly lower in VTE patients than those admitted for other causes which could be due to a targeted treatment approach for VTE. Male sex and higher comorbidity index are associated with more mortality rate.
Details
- Title: Subtitle
- 2997 Venous Thromboembolism Among Hospitalized Patients With Gastric Cancer: Insights From National Inpatient Sample 2004-2014
- Creators
- Kamesh Gupta - Baystate Medical CenterShivani Handa - St. Luke's-Roosevelt Hospital CenterHemant Goyal - The Wright Center for Graduate Medical EducationAhmad Khan - West Virginia UniversityAbdullah Sohail - Charleston Area Medical CenterDavid Desilets - Baystate Medical Center
- Resource Type
- Abstract
- Publication Details
- The American journal of gastroenterology, Vol.114(1), pp.S1622-S1622
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- DOI
- 10.14309/01.ajg.0000601520.00865.48
- ISSN
- 0002-9270
- eISSN
- 1572-0241
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695824702771
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