Abstract
313 LOW FAT FISH OIL (LFFO) DIET DECREASES PRO-INFLAMMATORY EICOSANOIDS AND PROSTATE CANCER CELL CYCLE PROGRESSION (CCP) SCORE IN MEN UNDERGOING RADICAL PROSTATECTOMY
The Journal of urology, Vol.189(4S), pp.e127-e127
04/2013
DOI: 10.1016/j.juro.2013.02.1698
Abstract
INTRODUCTION AND OBJECTIVES
In a prospective randomized trial we previously showed that a 4-6 week LFFO diet resulted in increased prostate tissue omega-3 fatty acid levels and reduced prostate cancer proliferation (Ki67). We sought to determine if the LFFO diet (compared to a western diet (WD)) affected serum fatty acids and pro-inflammatory eicosanoid levels as well as prostate cancer CCP score, and if changes in serum fatty acids and inflammatory factors predict antiproliferative effects in prostate cancer tissue.
METHODS
Pre and post intervention serum fatty acids and eicosanoids (leukotriene B4 (LTB4) and 15-S-Hydroxyeicosatetraenoic acid (15S-HETE)) were measured by gas chromatography and ELISA. Prostate cancer CCP score (an independent predictor of prostate cancer progression and mortality following radical prostatectomy) was measured by RT-PCR. The relationship between serum fatty acids and pro-inflammatory factors, and prostate cancer proliferation was evaluated using partial correlations controlling for pathological gleason score, weight loss and race.
RESULTS
Serum omega-6 fatty acids and 15S-HETE levels were significantly reduced whereas serum omega-3 levels were significantly increased in the LFFO group relative to the WD group (Table 1). The prostate cancer CCP score was significantly lower in the LFFO prostatectomy tissue compared to the WD prostatectomy tissue. The post-intervention serum omega-6/omega-3 ratio positively correlated with the radical prostatectomy prostate cancer proliferation (Ki67) and CCP score (R=0.51; p<0.01 and R=0.4; p=0.02 respectively). The 15-S-HETE change positively correlated with tissue Ki67 (R=0.48; p<0.01) while LTB4 change correlated with the CCP score (R=0.4; p=0.02).
CONCLUSIONS
A 4-6 week LFFO diet decreased serum 15S-HETE and prostate cancer tissue CCP score. Further prospective studies are needed to evaluate serum omega-6/omega-3 ratio, 15S-HETE or LTB4 levels as surrogate biomarkers for prostate cancer proliferation.
Details
- Title: Subtitle
- 313 LOW FAT FISH OIL (LFFO) DIET DECREASES PRO-INFLAMMATORY EICOSANOIDS AND PROSTATE CANCER CELL CYCLE PROGRESSION (CCP) SCORE IN MEN UNDERGOING RADICAL PROSTATECTOMY
- Creators
- J. Bryant Byrd - Los Angeles, CAColette Galet - Los Angeles, CASevan Stepanian - Los Angeles, CAKiran Gollapudi - Los Angeles, CASusanne M. Henning - Los Angeles, CATristan Grogan - Los Angeles, CADavid Elashoff - Los Angeles, CADavid Heber - Los Angeles, CAPinchas Cohen - Los Angeles, CAWilliam J. Aronson - Los Angeles, CA
- Resource Type
- Abstract
- Publication Details
- The Journal of urology, Vol.189(4S), pp.e127-e127
- DOI
- 10.1016/j.juro.2013.02.1698
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Publisher
- ELSEVIER SCIENCE INC
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Injury Prevention Research Center; University of Iowa Health Care
- Record Identifier
- 9985140871302771
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