Abstract
(328) Select Metabolomics Reveal Potential Biomarkers of Fibromyalgia that Correlate with Pain and Fatigue
The journal of pain, Vol.20(4), pp.S57-S57
04/2019
DOI: 10.1016/j.jpain.2019.02.024
Abstract
Currently, there are no established biomarkers for the diagnosis or symptoms of pain and fatigue in individuals with fibromyalgia (FM). The objective of this study was to identify potential biomarkers in individuals with FM, and to correlate these putative biomarkers with FM-symptoms using a targeted metabolomics approach. The current study was a secondary analysis from baseline data taken in the Fibromyalgia Activity Study with TENS (FAST). We analyzed plasma samples and baseline patient-reported outcomes for resting pain and fatigue from 59 women with FM (mean±SD; age=49.69±11.54, BMI=35.23±10.91) matched with 38 healthy controls (HC) (age=51.0±11.46, BMI=32.33±8.66). Serum/plasma metabolomic extracts were derivatized and analyzed by gas chromatography mass spectrometry for 63 key metabolites representing the tricarboxylic acid cycle, glycolysis, pentose phosphate pathway, amino acid metabolism, neurotransmission, reactive oxygen species defense, and energetics. Differences between FM and HC were assessed for each metabolite using unpaired t-tests (corrected p<0.008) and Pearson's correlation coefficients were assessed between significant metabolites and baseline pain and fatigue. Ten of the 63 metabolites showed significant between-group differences (P<0.0001). 2-hydroxybutyrate, asparagine, cysteine, fumarate, histidine and tryptophan were negatively correlated with pain and fatigue (P=0.002 to 0.0001, r=-0.315 to -0.894) while 6-phosphogluconate, hypoxanthine, and sphingosine were positively correlated (P=0.004 to 0.0001, r=0.291 to 0.366). The results of this study demonstrate individuals with FM have different resting levels of a variety of metabolites compared to HC, which correlate with their symptoms. These metabolites are generally involved in reduction-oxidation pathways and energy metabolism. Future work will confirm these findings in a new cohort and examine if interventions can alter these metabolites and symptomology. Funded by NIH grant AR06338 and AR06338S1.
Details
- Title: Subtitle
- (328) Select Metabolomics Reveal Potential Biomarkers of Fibromyalgia that Correlate with Pain and Fatigue
- Creators
- J Lesnak - University of IowaE Merriwether - University of IowaE Taylor - University of IowaD Dailey - University of IowaC VanceM Zimmerman - University of IowaL Crofford - University of IowaL. Frey Law - University of IowaK Sluka - University of Iowa
- Resource Type
- Abstract
- Publication Details
- The journal of pain, Vol.20(4), pp.S57-S57
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2019.02.024
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Biostatistics; Nursing; Neuroscience and Pharmacology; Fraternal Order of Eagles Diabetes Research Center; Physical Therapy and Rehabilitation Science; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984227044202771
Metrics
8 Record Views