Abstract
368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection
The journal of pain, Vol.29(Supplement), 105166
04/2025
DOI: 10.1016/j.jpain.2025.105166
Abstract
Individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and postacute sequelae of SARS-CoV-2 infection (PASC) experience exercise-induced pain and fatigue (EIPF). EIPF can occur during and after exercise and is a barrier to participation in daily activities and exercise. While mechanisms of pain and fatigue are likely multifactorial, several studies suggest a prominent role of the immune system. This study examined pain, fatigue, and immune cell profiles before and after an exercise task in 30 individuals with PASC, ME/CFS, and controls. Pain and fatigue were assessed prior to and for 7-days following exercise using 0-10 numerical rating scales. PBMCs were isolated and monocyte, T-cell, natural killer cell, and B-cell phenotypes were characterized using flow cytometry before and after exercise. EIPF was defined as a composite change score for pain and fatigue over 72-hours following exercise and ranged from -4.0-5.3/10 in individuals with ME/CFS and PASC. There were no differences in monocyte, T-cell, natural killer cell, or B-cell phenotypes at baseline or changes in phenotype following exercise among groups (p>.05). Cluster analysis identified two distinct groups based on the baseline monocyte phenotype, an inflammatory group (classical monocytes>non-classical monocytes) and a non-inflammatory group (classical monocytes<non-classical monocytes). The inflammatory group reported higher EIPF (inflammatory: 2.3, non-inflammatory: 0.9, p<.05), and the classical to non-classical monocyte ratio correlated with EIPF (r=.342,p=.05). These data suggest immune function can drive the pain and fatigue response to an acute bout of exercise and may have implications for future development of anti-inflammatory therapeutics to address EIPF.
Details
- Title: Subtitle
- 368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection
- Creators
- Giovanni BerardiAdam JanowskiSamuel McNallyGregorius BernhardAlpana GargKathleen Sluka
- Resource Type
- Abstract
- Publication Details
- The journal of pain, Vol.29(Supplement), 105166
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpain.2025.105166
- ISSN
- 1526-5900
- eISSN
- 1528-8447
- Language
- English
- Date published
- 04/2025
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984820561402771
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