Abstract
474: HSP60 and anti-HSP60 antibody are associated with intrapartum infection in preeclamptic mothers
American Journal of Obstetrics and Gynecology, Vol.197(6 S), pp.S139-S139
2007
DOI: 10.1016/j.ajog.2007.10.493
Abstract
INFECTION IN PREECLAMPTIC MOTHERS MARK SANTILLAN, DONNA SANTILLAN, JOHN GIANOPOULOS, RUBIN MESTRIL, MEGAN KOH, University of Iowa, Iowa City, Iowa, Loyola University Medical Center, Maywood, Illinois OBJECTIVE: The role of heat shock protein 60 (HSP60) in pregnancy is unclear. Studies have associated this stress protein and anti-HSP60 antibodies with perinatal morbidity including infection, in-vitro fertilization failure, growth restriction, preeclampsia, and preterm labor. In this study, we investigate whether the presence of HSP60 (s-HSP60) or anti-HSP60 antibodies (s-anti-HSP60) in maternal serum has an association with perinatal morbidity. STUDY DESIGN: In this adjunct, subset analysis of a case control study of HSP60 and preeclampsia, maternal sera were collected in 68 controls and 62 preeclamptics. S-HSP60 was measured by ELISA. S-anti-HSP60 was identified by Surf-Blot type Western Blot. Demographic, maternal, and obstetric variables were obtained from the medical record. Logistic regression and 2 tail Fisher exact test were performed with 0.05. RESULTS: Preeclamptics positive for s-HSP60 had a higher rate of intrapartum infection than those with undetectable s-HSP60 (25% vs. 3.1%, p 0.026). Preeclamptics positive for both s-HSP60 and s-anti-HSP60 also had a higher rate of intrapartum infection than other preeclamptics (39% vs. 4.5%, p 0.005). The rates of intrapartum infection of preeclamptics and controls were similar. In mothers without preeclampsia, there was not a significant correlation of s-HSP60 or s-antiHSP60 with perinatal morbidity including antenatal infection, peripartum infection, active labor, preterm delivery, mode of delivery, birthweight, low APGAR scores and postpartum complications. CONCLUSION: Contrary to other studies, HSP60 was not associated with a variety of obstetrical stressors including antenatal infection and preterm delivery. Our data show that in preeclamptic mothers, the presence of s-HSP60 and s-anti-HSP60 are associated with a higher rate of intrapartum infection. As the sera were drawn upon admission to the hospital prior to the onset of clinical symptoms of infection, presence of sHSP60 and s-antiHSP60 may be an early indicator of subclinical infection. Our data did not show similar results in controls.
Details
- Title: Subtitle
- 474: HSP60 and anti-HSP60 antibody are associated with intrapartum infection in preeclamptic mothers
- Creators
- Mark SantillanDonna SantillanJohn GianopoulosRubin MestrilMegan Koh
- Resource Type
- Abstract
- Publication Details
- American Journal of Obstetrics and Gynecology, Vol.197(6 S), pp.S139-S139
- DOI
- 10.1016/j.ajog.2007.10.493
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Language
- English
- Date published
- 2007
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983931819402771
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