Logo image
Back
479 IS INFILTRATION OF TUMOR-ASSOCIATED MACROPHAGES PREDICTIVE OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY?
Abstract   Peer reviewed

479 IS INFILTRATION OF TUMOR-ASSOCIATED MACROPHAGES PREDICTIVE OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY?

Kiran Gollapudi, Colette Galet, Tristan Grogan, Hong Zhang, Jiaoti Huang, David Elashoff, Leah Gerber, Stephen Freedland, Matthew Rettig and William Aronson
The Journal of urology, Vol.187(4S), pp.e196-e196
04/2012
DOI: 10.1016/j.juro.2012.02.548

View Online

Abstract

INTRODUCTION AND OBJECTIVES Macrophages are key components of the inflammatory process and are present in the tumor microenvironment of various cancer types. Through the release of cytokines, chemokines, and various growth factors, they can either have positive or negative effects on tumor progression. Previous studies examining the link between tumor-associated macrophages (TAMs) in prostate cancer and patient outcomes have been contradictory. We sought to determine if the quantity of TAMs in prostate cancer tissue was predictive of biochemical recurrence in men undergoing radical prostatectomy. METHODS Radical prostatectomy specimens of 332 men who underwent surgery at the West Los Angeles Veteran's Affairs Hospital between 1991 and 2003 were used to construct a tissue microarray (TMA) consisting of cancer, PIN and benign tissue. TAMs were stained using a monoclonal CD68 antibody. The number of TAMs per core was manually counted by two blinded pathologists. Cox proportional hazards models were used to determine if age, preoperative PSA, race, body mass index (BMI), pathologic Gleason sum, seminal vesicle invasion (SVI), extracapsular extension (ECE), margin status, and mean TAMs (cancer, PIN, and benign) were associated with time to PSA recurrence. RESULTS The mean number of TAMs was significantly higher in cancer tissue compared to PIN and benign tissue (p<0.0001). Mean number of TAMs were also higher in high grade cancer cores (Gleason 4 and 5) vs. low grade cancer cores (Gleason 2 and 3) (p=0.004). On univariate analysis, mean number of TAMs in cancer cores, PSA, BMI, pathologic Gleason sum, SVI, ECE, and positive margins were significantly associated with an increased risk of biochemical recurrence. On multivariate analysis, mean number of TAMs per cancer core remained associated with a trend toward increased risk of biochemical recurrence, (HR 1.06, 95% CI 0.99-1.13, p=0.08). CONCLUSIONS Higher TAMs per cancer core were associated with higher grade prostate cancer and suggestively with biochemical recurrence. Validation of our results is required to determine if the number of TAMs within cancer may be used in clinical practice for predicting recurrent prostate cancer. Further studies are required to determine if the higher TAM levels associated with high grade prostate cancer have a tumor promoting or inhibitory effect as well as to better understand the role the immune system and TAMs in particular play in modulating prostate cancer biology.

Details

Metrics

1 Record Views
Logo image