Abstract
[64-OR]: Molecular basis for racial disparity in pre-eclampsia
Pregnancy hypertension, Vol.5(1), pp.33-34
01/2015
DOI: 10.1016/j.preghy.2014.10.068
Abstract
Pre-eclampsia (PE) affects 5-8% of pregnancies, and factors causing PE and mediating observed racial disparity are poorly understood. The cardiovascular gene Nkx2-5 is expressed in trophoblast cells and abnormal amnions are observed in mice Nkx2-5 mutant mice. We assessed Nkx2-5-related gene expression in placenta from normal and early onset and severe pre-eclampsia (EOSPE) pregnancies.
IHC and qPCR assay of Nkx2.5 and target gene expression in normal term and EOSPE placenta.
Nkx2-5 is highly expressed in a subset of early EOSPE placentae, and is highly correlated with expression of the PE marker sFlt-1, and with an RNA splicing factor, Sam68. These correlations are significant in Caucasian, but not African American women. siRNA knockdown of Sam68 significantly impacts sFlt-1 expression in vitro, supporting a hypothesis that Nkx2-5 impacts EOSPE severity via upregulation of Sam68 and increased sFlt-1 expression. Other Nkx2-5 targets related to metabolic stress responses are also differentially activated in between Caucasians and African American women with EOSPE.
Nkx2-5 may play a direct role in the genesis of PE via regulation of Sam68/sFlt-1, and serve as a common link to two other stress-related modifiers of EOSPE.
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E.R. Rivers: None. A.J. Horton: None. C.D. Clark: None. E.G. Favre: None. K.M. Senf: None. A.F. Hawk: None. E.Y. Chang: Consultant, Commercial Interest: Alere PETRA study, Hologic, Inc. C.J. Robinson: None. K. Lee: None.
Details
- Title: Subtitle
- [64-OR]: Molecular basis for racial disparity in pre-eclampsia
- Creators
- Elena R. Rivers - Medical University of South CarolinaAnthony J. Horton - Medical University of South CarolinaChristopher D. Clark - Medical University of South CarolinaElizabeth G. Favre - Medical University of South CarolinaKatherine M. Senf - Medical University of South CarolinaAngela F. Hawk - Medical University of South CarolinaEugene Y. Chang - Medical University of South CarolinaChristopher J. Robinson - University of VirginiaKyu-Ho Lee - Medical University of South Carolina
- Resource Type
- Abstract
- Publication Details
- Pregnancy hypertension, Vol.5(1), pp.33-34
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.preghy.2014.10.068
- ISSN
- 2210-7789
- eISSN
- 2210-7797
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984697031902771
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