Abstract
704 DEXMEDETOMIDINE IN CHILDREN WITH OBSTRUCTIVE LUNG DISEASE TO FACILITATE NONINVASIVE VENTILATION
Critical care medicine, Vol.43(12 Suppl 1), pp.177-178
12/2015
DOI: 10.1097/01.ccm.0000474532.89582.5a
Abstract
Learning Objectives: Although noninvasive positive pressure ventilation (NIV) has been shown to be safe and effective, anxiety and agitation often leads to difficulty or failure to initiate and/or maintain it in children. The aim of this study was to assess the efficacy and safety of dexmedetomidine in providing sedation to facilitate the initiation and continued delivery of noninvasive positive pressure ventilation to patients admitted to the Pediatric Intensive Care Unit (PICU) for asthma or bronchiolitis.
Methods: A retrospective chart review was done, after IRB approval, of patients admitted to the PICU with status asthmaticus or bronchiolitis requiring NIV and placed on dexmedetomidine to facilitate continuation of NIV because of agitation/anxiety. Data is presented as median, interquartile range (IQR), mean, and standard deviation. Statistical significance was considered at p <0.05.
Results: Nine patients, median age 14 (IQR 7 to 84) mo, received dexmedetomidine to facilitate NIV. The median time after NIV to start of dexmedetomidine was 4 (IQR 1 to 12) hr. Median duration of NIV was 38 (IQR 10 to 59) hr and median duration of dexmedetomidine was 24.5 (IQR 15 to 45) hr. Median length of stay in the hospital was 114 (IQR 86 to 208) hr. Mean heart rate was 170 ± 15 at baseline and 150 ± 14 an hour after dexmedetomidine and NIV, p <0.05. Mean systolic and diastolic blood pressures were 117 ± 18 and 55 ± 10 at baseline respectively and 99 ± 15 and 47 ± 13 an hour after dexmedetomidine and NIV respectively, p > 0.05.
Conclusions: Children were on NIV for several hr after initiation of dexmedetomidine suggesting that it may help initiate and maintain NIV on patients needing NIV for management of status asthmaticus and bronchiolitis. The heart rate and blood pressure decreased but not dangerously suggesting that the children were less agitated after initiation of NIV and dexmedetomidine.
Details
- Title: Subtitle
- 704 DEXMEDETOMIDINE IN CHILDREN WITH OBSTRUCTIVE LUNG DISEASE TO FACILITATE NONINVASIVE VENTILATION
- Creators
- Sangita BasnetMichael HalykoGiovanna CapriroloRyan Majcina
- Resource Type
- Abstract
- Publication Details
- Critical care medicine, Vol.43(12 Suppl 1), pp.177-178
- DOI
- 10.1097/01.ccm.0000474532.89582.5a
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Number of pages
- 2
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984701837702771
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