Abstract
706: Lack of association of fas gene and preeclampsia
American journal of obstetrics and gynecology, Vol.199(6 Supplement A), pp.S202-S202
2008
DOI: 10.1016/j.ajog.2008.09.737
Abstract
Objective
The Fas gene polymorphism at position −670 has previously been associated with preeclampsia. Given Fas is a major mediator of apoptosis and increased apoptosis of the placental trophoblast has been documented in preeclampsia, we sought to confirm this association in patients with preeclampsia both at term and preterm. We further sought to determine if there was an association with the gestational age of onset of preeclampsia.
Study Design
DNA from 358 preeclamptic patients and 447 controls who were enrolled in a collaborative study at the University of Iowa and Wake Forest University on the molecular genetics of preeclampsia were studied. Taqman genotyping assays were performed for the Fas (TNFRSF6) gene for the A>G polymorphism at position −670. Samples were tested for Hardy-Weinberg equilibrium. Allelic and genotypic frequencies were analyzed using Chi-square statistical analysis.
Results
79 of 358 (22%) women with preeclampsia compared to 93 of 447 (21%) women in the control group were homozygous for the minor allele guanine at position −670 in the Fas gene. 182 of 358 (51%) women with preeclampsia compared to 227 of 447 (51%) women in the control group were heterozygous for the guanine alelle at posistion −670 in the Fas gene. There was no difference in term preeclampsia when compared with those diagnosed preterm. There were no significant differences in allelic frequencies between the groups. Chi-square analysis found p>0.05 for comparison of both genotype and allelic frequencies.
Conclusion
No genetic association was identified with the Fas gene and an increased risk of preeclampsia in our patient population. Potential explanations for our lack of association could be that different ethnic populations have variations in allelic frequencies which can lead to bias in case control studies. These results could also suggest a false positive association in the previous studies given their small sample sizes. There may also be gene-gene or gene-environment interactions that involve the Fas gene and lead to both positive and negative association studies.
Details
- Title: Subtitle
- 706: Lack of association of fas gene and preeclampsia
- Creators
- Kristi Borowski - University of IowaLaura Kair - University of IowaShemin Zeng - University of IowaDavid Merrill - Wake Forest UniversityJeffrey Murray - University of IowaJanet Andrews - University of Iowa
- Resource Type
- Abstract
- Publication Details
- American journal of obstetrics and gynecology, Vol.199(6 Supplement A), pp.S202-S202
- DOI
- 10.1016/j.ajog.2008.09.737
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Obstetrics and Gynecology; Dental Research; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984697025302771
Metrics
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