Abstract
74841 Assessment of prognostic value of baseline hematologic profile in cutaneous T-cell lymphoma
Journal of the American Academy of Dermatology, Vol.95(1 Suppl), p.AB58
07/2026
DOI: 10.1016/j.jaad.2026.04.247
Abstract
Cutaneous T-cell lymphomas (CTCL) pose a unique challenge to diagnosis and management due to their protean clinical manifestations, variety of pathologic findings, and lack of reliably effective and durable treatments. Optimal management of CTCL requires accurate staging, and currently the NCCN (National Cancer Consortium Network) recommends Tumor-Node-Metastases-Blood (TNMB) integration with the blood category stratification based upon peripheral blood flow cytometry (PBFC). Although PBFC currently serves as the gold standard for measuring blood involvement in CTCL staging, other blood parameters which may also reflect hematological tumor burden and therefore inform staging and predict prognosis in CTCL patients deserve exploration. This study describes a retrospective analysis of 109 CTCL patients where baseline hematologic profiles in CBC and LDH were collected at diagnosis and assessed for correlation with initial B-stage (determined by PBFC), initial overall stage, maximum B-stage (determined by PBFC), and maximum overall stage. The effect of hematologic profiles at diagnosis on five-year overall survival was also assessed. This study revealed that higher WBC count and LDH measurements at the time of CTCL diagnosis were associated with both higher initial overall staging of the disease as well as higher maximum B-staging and maximum overall staging evaluated throughout the course of the disease. These results support the potential utility of initial WBC count and LDH as adjunctive tools in evaluating initial disease severity and predictors for maximum disease progression. Furthermore, results showed that age and WBC count at diagnosis were associated with the highest increase in risk of death within 5 years.
Details
- Title: Subtitle
- 74841 Assessment of prognostic value of baseline hematologic profile in cutaneous T-cell lymphoma
- Creators
- Jason Chen - University of Iowa, Carver College of MedicineEric Mou - University of Iowa Hospitals and ClinicsBradley Loeffler - University of Iowa Hospitals and ClinicsVincent Liu - University of Iowa Hospitals and Clinics
- Resource Type
- Abstract
- Publication Details
- Journal of the American Academy of Dermatology, Vol.95(1 Suppl), p.AB58
- DOI
- 10.1016/j.jaad.2026.04.247
- ISSN
- 0190-9622
- Publisher
- Elsevier
- Language
- English
- Date published
- 07/2026
- Academic Unit
- Dermatology; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9985180970502771
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