Abstract
A Pathway Links Gut Microbiome to Afferent Sensory Neurons Through CB1 to Regulate Energy Balance
Obesity (Silver Spring, Md.), Vol.30(S1), pp.211-211
11/01/2022
Abstract
Background: We recently showed that splanchnic nerve plays a key role in physiology energy regulation and post gastric bypass where its activity is significantly upregulated to increase "browning" of mesenteric fat. Administration of an endocannabinoid receptor-1 (CB1) inverse agonist (Rimonabant) caused increase in splanchnic nerve activity, and an energy change phenotype similar to bypass-operated mice. We also showed that splanchnic denervation significantly reduces the response to Rimonabant. Methods: We explored : 1) where these peripheral CB1 are located in the gut and how do they mediate their energy regulatory effects using surgical mouse models. 2) if gut microbiome changes post-gastric bypass mediate the energy effect of the surgery through the CB1-expressing cells. Results: We found that intestinal CB1 co-localizes mainly with CGRPexpressing cells (sensory neurons) and not epithelial, enteroendocrine or any immune cell. We then developed and confirmed a model of afferent selective denervation (aSpDNV) using topical capsaicin over celiac ganglia and its branches. Interestingly, aSpDNV mice express a phase of increase food intake but no change in body weight. Furthermore, transferring fecal material from RYGB and Sham -operated mice into naif recipients induces a significant increase in afferent and efferent splanchnic nerve activity of RYGB-stool recipients compared to their controls. Finally, intestinal CB1 expression was significantly lower in RYGB-stool recipients compared to their controls. Conclusions: Gut microbiome can communicate energy signals directly to the brain through CBl-expressing sensory neurons.
Details
- Title: Subtitle
- A Pathway Links Gut Microbiome to Afferent Sensory Neurons Through CB1 to Regulate Energy Balance
- Creators
- Mohamad MokademYi ChuBenjamin LindenHussein HerzDonald MorganKamal Rahmouni
- Resource Type
- Abstract
- Publication Details
- Obesity (Silver Spring, Md.), Vol.30(S1), pp.211-211
- Publisher
- Blackwell Publishing Ltd
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Comment
- DOI: 10.1002/oby.23626
- Language
- English
- Date published
- 11/01/2022
- Academic Unit
- Neuroscience and Pharmacology; Fraternal Order of Eagles Diabetes Research Center; Gastroenterology and Hepatology; Internal Medicine; Iowa Neuroscience Institute
- Record Identifier
- 9984339359102771
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