Abstract
A RANDOMIZED CONTROLLED TRIAL(RCT) OF COUNSELING AND EDUCATIONAL METHODS ON PREIMPLATATION GENETIC TESTING FOR ANEUPLOIDY(PGT-A) FOR IVF PATIENTS
Fertility and sterility, Vol.122(4 Supplement), pp.e22-e23
10/2024
DOI: 10.1016/j.fertnstert.2024.07.125
Abstract
OBJECTIVE
To prospectively compare methods of education on PGT-A- using 3 groups (G), G1: REI provider counseling (REI-C) only, G2: REI-C and a written educational handout (HO) and G3: REI-C, HO, and a brief counseling session with a genetic counselor (GC) in clinic.
MATERIALS AND METHODS
A total of 105 single or partnered patients were recruited for the RCT at their 1st IVF cycle visit (Jul 2023-Feb 2024). The HO was validated in a pilot study. To detect an effect size of 0.33 (knowledge increase of 29% in G2 or G3 compared to G1) with p=0.05 and 80% power, 90 patients were needed (30 per arm) with 15 additional patients to account for drop out. We excluded those who had previously received GC PGT-A counseling or who had indications for other types of PGT. Subjects were assigned by block randomization of 1:1:1. Groups received 3 surveys (pre-, post- and 2 weeks post-visit); surveys had 7 knowledge questions. Primary outcome was knowledge post-visit. Secondary outcomes were knowledge 2 weeks post-visit and decisional conflict. ANCOVA measured the relationship between intervention and scores (% correct) with adjusted means reported with 95% confidence intervals, controlling for initial scores. Post hoc comparisons made with Bonferroni test using G1 as the reference group. Multiple imputation was applied as needed.
RESULTS
A total of 105 patients (a) and 97 partners (b) enrolled. Patient and partner mean age (SD) was 32.2 (4.2) and 33.9 (5.2) years, respectively. The majority identified as white [a- 89.3%, b- 91.6%] and had a college degree [a- 48%, b- 39.2%]. There was a statistically significant improvement in patient and partner knowledge in both G2 and G3 compared to G1 at post-visit survey. At 2 weeks post-visit, there also was improvement in knowledge for patients in G2 and G3 compared to G1, and for partners in G3 compared to G1 (Table 1). G3 reported understanding PGT-A well to very well [a- p=.015 post-visit, b- p=.009 at 2 weeks post-visit]. Groups did not show a difference in decisional conflict (p=.17).
CONCLUSIONS
Patient and partner knowledge improved with educational handout and a brief genetic counseling session. Self-reported understanding improved with GC counseling.
IMPACT STATEMENT
This RCT supports inclusion of written educational materials and a clinical GC as resources for PGT-A education.
Details
- Title: Subtitle
- A RANDOMIZED CONTROLLED TRIAL(RCT) OF COUNSELING AND EDUCATIONAL METHODS ON PREIMPLATATION GENETIC TESTING FOR ANEUPLOIDY(PGT-A) FOR IVF PATIENTS
- Creators
- Prapti SinghKaren M. SummersNour ChanouhaRenata ThoenyAlithea ZornBradley J. Van VoorhisAmy E. SparksAbey EapenElissa FaroStacey A. PawlakHakan Duran
- Resource Type
- Abstract
- Publication Details
- Fertility and sterility, Vol.122(4 Supplement), pp.e22-e23
- DOI
- 10.1016/j.fertnstert.2024.07.125
- ISSN
- 0015-0282
- Language
- English
- Date published
- 10/2024
- Academic Unit
- Psychiatry; Epidemiology; Obstetrics and Gynecology; General Internal Medicine; Psychological and Brain Sciences; Internal Medicine; Psychological and Quantitative Foundations
- Record Identifier
- 9984737129402771
Metrics
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