Abstract
A Randomized, Double Blind Trial, of Hydroxychloroquine for the Prevention of Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation
Blood, Vol.106(11), pp.1800-1800
11/16/2005
DOI: 10.1182/blood.V106.11.1800.1800
Abstract
Abstract
Hydroxychloroquine (HCQ) is an immunosuppressive lysosomotropic amine that has activity against graft-versus-host disease (GVHD). We previously reported low incidences of acute GVHD in unrelated donor transplant recipients who received prophylactic HCQ in addition to standard GVHD prophylaxis (BBMT2003; 9: 714–721). We herein report results of a single-institution phase III trial, in which 95 recipients of matched sibling allogeneic peripheral blood stem cell transplantation were randomized to receive, in a double-blind fashion, and in addition to prophylactic cyclosporine A (CSA), HCQ or placebo starting 21 days pre-transplant and continued until d+365. HCQ was very well tolerated and not associated with side effects. The addition of HCQ had no effects on lymphocyte subsets both pre- and post-transplant. Overall, the incidence of acute GVHD was 59% in both arms, and severe acute GVHD occurred in 11% (HCQ) and 14% (placebo) (p=0.76). Sixty-one and 46% of patients developed chronic GVHD in the placebo and the HCQ arms, respectively (p = 0.15). With a median follow-up of 18 months, relapse-free and overall survivals were comparable in both groups. In summary, in this randomized trial, the addition of HCQ to single agent CSA was not associated with a reduction of either acute or chronic GVHD; additionally, no significant effects on relapses or survival were observed.
Details
- Title: Subtitle
- A Randomized, Double Blind Trial, of Hydroxychloroquine for the Prevention of Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation
- Creators
- Tom Fong - Washington University in St. LouisKim Trinkaus - Washington University in St. LouisDouglas R. Adkins - Washington University in St. LouisRavi Vij - Washington University in St. LouisSteven Devine - Washington University in St. LouisMichael Tomasson - Washington University in St. LouisLawrence T. Goodnough - Washington University in St. LouisTimothy Graubert - Washington University in St. LouisShalini Shenoy - Washington University in St. LouisJohn F. DiPersio - Washington University in St. LouisHanna J. Khoury - Emory University
- Resource Type
- Abstract
- Publication Details
- Blood, Vol.106(11), pp.1800-1800
- DOI
- 10.1182/blood.V106.11.1800.1800
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Language
- English
- Date published
- 11/16/2005
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984363438802771
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