ABSTRACT NUMBER: ESOC2026A1633 A NOVEL STRATIFICATION TOOL TO PREDICT 6-MONTH OUTCOMES IN ACUTE CEREBRAL VENOUS THROMBOSIS: THE CLOT-VENUS SCORE

Leonardo Cruz-Criollo; Aaron Rodriguez-Calienes; Anderson Brito; Nashwa Abdelhakim; Milagros Galecio-Castillo; Vanessa Cano Nigenda; Andres Alberto Mercado; Brian J Smith; Antonio Arauz Gongora; Santiago Ortega-Gutierrez

doi:10.1093/esj/aakag023.777

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ABSTRACT NUMBER: ESOC2026A1633 A NOVEL STRATIFICATION TOOL TO PREDICT 6-MONTH OUTCOMES IN ACUTE CEREBRAL VENOUS THROMBOSIS: THE CLOT-VENUS SCORE

Leonardo Cruz-Criollo, Aaron Rodriguez-Calienes, Anderson Brito, Nashwa Abdelhakim, Milagros Galecio-Castillo, Vanessa Cano Nigenda, Andres Alberto Mercado, Brian J Smith, Antonio Arauz Gongora and Santiago Ortega-Gutierrez

European stroke journal, Vol.11(Suppl 1), pp.i444-i445

05/06/2026

DOI: 10.1093/esj/aakag023.777

PMCID: PMC13145450

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Abstract

Background and aims Cerebral Venous Thrombosis (CVT) outcomes are highly heterogeneous, and existing prognostic scores lack precision. We developed a comprehensive model to predict 6-month poor functional outcome (mRS 3–6) to improve early risk stratification and secondary prevention. Methods We conducted a retrospective observational cohort study of patients diagnosed with acute CVT from the international CoLlabOraTion on Cerebral VENoUs Thrombosis Study (CLOT-VENUS) registry (2004-2024), including two comprehensive stroke centers in the USA and Mexico. Most relevant clinical, imaging, and laboratory results were collected. Parsimonious predictors were identified using LASSO regression and recursive feature elimination. To facilitate clinical utility, a normogram was developed to provide a visual representation of the model’s predictive contributions. Then it was validated on a 1/3 held-out testing set Results Of 432 patients, 394 met the inclusion criteria. Median age was 40 years [IQR 28-55], and 65% were female. Volume of ICH, altered mental status, mRS baseline, hematocrit, BMI, monocyte-to-lymphocyte ratio, and deep CVT location were identified as important predictors of poor outcome and included in a final prediction model. Performance of the final model to predict mRS 3-6 months was estimated with cross-validation to have area under the receiver operating characteristic curve of 0.88 [95%CI 0.83–0.93] was estimated in the testing set to have area under the receiver operating characteristic curve of 0.79 [95%CI: 0.67–0.91] Conclusions This validated scale provides a reliable tool at admission for predicting 6-month outcomes in acute CVT, facilitating individualized risk stratification and enhancing secondary prevention strategies.

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Title: Subtitle: ABSTRACT NUMBER: ESOC2026A1633 A NOVEL STRATIFICATION TOOL TO PREDICT 6-MONTH OUTCOMES IN ACUTE CEREBRAL VENOUS THROMBOSIS: THE CLOT-VENUS SCORE
Creators: Leonardo Cruz-Criollo - University of Iowa
Aaron Rodriguez-Calienes - University of Iowa
Anderson Brito - University of Iowa
Nashwa Abdelhakim - University of Iowa
Milagros Galecio-Castillo - University of Iowa
Vanessa Cano Nigenda - Instituto Nacional de Neurología y Neurocirugía
Andres Alberto Mercado - Instituto Nacional de Neurología y Neurocirugía
Brian J Smith - University of Iowa
Antonio Arauz Gongora - Instituto Nacional de Neurología y Neurocirugía
Santiago Ortega-Gutierrez - University of Iowa
Resource Type: Abstract
Publication Details: European stroke journal, Vol.11(Suppl 1), pp.i444-i445
DOI: 10.1093/esj/aakag023.777
PMCID: PMC13145450
ISSN: 2396-9873
eISSN: 2396-9881
Publisher: Oxford University Press
Language: English
Date published: 05/06/2026
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Biostatistics; Neurosurgery; Holden Comprehensive Cancer Center
Record Identifier: 9985161451102771

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