Abstract
ASSA13-06-4 Female Sex Predicts Poor Prognosis in Patients with Hypertrophic Cardiomyopathy
Heart (British Cardiac Society), Vol.99(Suppl 1), pp.A34-A34
04/2013
DOI: 10.1136/heartjnl-2013-303992.105
Abstract
ObjectiveThis study was designed to assess the sex effect on clinical presentation and outcomes in patients with hypertrophic cardiomyopathy (HCM). Sex has been proved to play an important role in the clinical expression and prognosis of various cardiovascular diseases. Methods A total of 621 unrelated patients with HCM, without heart failure (460 males) were enrolled from 1999 to 2011. Results At baseline, female patients were older (49.6 ± 17.2 years vs. 46.7 ± 14.4 years, p = 0.033) at diagnosis, had greater frequency of left ventricular outflow tract obstruction (72/161, 44.7% vs. 149/460, 32.4%, p = 0.005) than male patients. During follow-up of 4 (2–7) years, survival analysis showed that the incidences of all-cause mortality, cardiovascular death and progression to chronic heart failure were greater in women than in men (p = 0.031, 0.040 and 0.014, respectively). After adjustment for multiple factors that may confound survival and cardiac function, female sex remained an independent risk factor for all-cause mortality, cardiovascular death, and chronic heart failure [hazard ratio (HR) 2.19, 95% confidence interval (CI) 1.21–3.95, p = 0.010; HR 2.19, 95%CI 1.17–4.09, p = 0.014; HR 1.73, 95%CI 1.12–2.69, p = 0.014, respectively] in HCM patients. Subgroup analysis revealed that female sex as a risk factor was only identified in patients younger than 50 years old (p = 0.011, 0.011 and 0.020, respectively), but not in more than 50 years old. Conclusions Our results suggest that female sex is an independent predictor of poor survival and heart failure in HCM patients. Further studies were required to determine whether female hormones modify the clinical expression and prognosis of HCM.
Details
- Title: Subtitle
- ASSA13-06-4 Female Sex Predicts Poor Prognosis in Patients with Hypertrophic Cardiomyopathy
- Creators
- Wang Yilu - 1Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBao Jingru - 2Clinical EP Laboratory and Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSun Kai - 3Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeZhu Ling - Xi'an Jiaotong UniversityTian Tao - 1Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeShen Hu - Xi'an Jiaotong UniversityZhang Weili - 3Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeZou Yubao - 1Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeWang Jizheng - 3Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeZhou Xianliang - Chinese Academy of Medical Sciences & Peking Union Medical CollegeAhmad Ferhaan - University of PittsburghHui Rutai - #N#3Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSong Lei - #N#3Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College
- Resource Type
- Abstract
- Publication Details
- Heart (British Cardiac Society), Vol.99(Suppl 1), pp.A34-A34
- DOI
- 10.1136/heartjnl-2013-303992.105
- ISSN
- 1355-6037
- eISSN
- 1468-201X
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984303006602771
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