Abstract
Abstract 059: Longitudinal associations of accelerometer-determined sedentary and physical activity behaviors with heart failure biomarkers during the midlife transition: Coronary Artery Risk Development in Young Adults (CARDIA)
Circulation (New York, N.Y.), Vol.151(Suppl_1)
03/11/2025
DOI: 10.1161/cir.151.suppl_1.059
Abstract
Introduction: Few studies have examined the longitudinal associations of accelerometry-based measures of sedentary and physical activity behaviors with subclinical heart failure (HF) in midlife. This is a key gap given an improved understanding of modifiable factors associated with HF risk may better inform prevention strategies.
Hypothesis: More time in light intensity physical activity and/or moderate or vigorous intensity physical activity and less sedentary time will be related to lower levels of clinical HF biomarkers (NT-proBNP and hscTnT) across midlife.
Methods: Data are from 2,844 CARDIA participants [57.9% women, 45.0% Black persons, aged 45.3 ± 3.6 years at the Year 20 exam (baseline for this analysis; 2005-06)] with at least one available timepoint of valid accelerometer (ActiGraph) wear (≥4 of 7 days with ≥10 hours per day of wear) and HF biomarkers at baseline and 10- and/or 15-years later. Linear mixed effects models, adjusted simultaneously for time spent sedentary and in light- or moderate or vigorous- intensity physical activity (partition model), sex, race, age, center, education, difficulty paying for basics, alcohol and tobacco use, obesity, diabetes, hypertension and hypercholesterolemia, were used to estimate the associations.
Results: From baseline to 15-year follow-up, mean (± SD) time spent sedentary increased (488.1 ± 104.3 to 537.5 ± 112.0 min/d) and time spent in light intensity physical activity and moderate or vigorous intensity physical activity decreased (360.1 ± 86.7 to 312.1 ± 87.2 min/d and 37.3 ± 51.7 to 22.1 ± 22.4 min/d, respectively). Over this same period, mean (± SD) HF biomarkers increased (NT-proBNP: 61.6 ± 91.8 to 145.8 ± 1,111.9 pg/mL and hscTnT: 7.8 ± 4.7 to 11.0 ± 28.7 ng/L)). After adjustment, every 5-minute higher moderate or vigorous intensity physical activity was associated with lower NT-proBNP and hscTnT over 15 years (Table).
Conclusions: Findings highlight the importance of moderate or vigorous intensity physical activity during the midlife transition for subclinical HF prevention, demonstrating this association before the onset of overt signs or symptoms.
Details
- Title: Subtitle
- Abstract 059: Longitudinal associations of accelerometer-determined sedentary and physical activity behaviors with heart failure biomarkers during the midlife transition: Coronary Artery Risk Development in Young Adults (CARDIA)
- Creators
- Kelley Gabriel - University of Alabama at BirminghamBjoern Hornikel - University of Alabama at BirminghamErin Dooley - University of Alabama at BirminghamBaojiang Chen - The University of Texas Health Science Center at HoustonSylvia Badon - Kaiser PermanenteAnkeet Bhatt - Kaiser Permanente San Francisco Medical CenterMercedes Carnethon - Northwestern UniversityDavid Jacobs - University of MinnesotaSadiya Khan - Northwestern UniversityJoao AC Lima - Johns Hopkins UniversityJared Reis - NATIONAL HEART LUNG BLOOD INST, Bethesda, Maryland, United StatesPamela Schreiner - University of MinnesotaJames Shikany - University of Alabama at BirminghamStephen Sidney - Kaiser PermanenteKara Whitaker - University of IowaCora Lewis - Univeristy of Alabama at Birmingham, Birmingham, Alabama, United StatesBarbara Sternfeld - Kaiser Permanente
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.151(Suppl_1)
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/cir.151.suppl_1.059
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 03/11/2025
- Academic Unit
- Epidemiology; Health and Human Physiology
- Record Identifier
- 9984813282902771
Metrics
7 Record Views