Abstract 10312: Meta-Analysis of Influenza Vaccine and Cardiovascular Outcomes

Ahmad Al-Abdouh; Waiel Abusnina; Mohammed Mhanna; ahmad jabri; Anan Abu Rmilah; Taha Ahmed; Taqwa Alabduh; Mostafa Zaalouk; Erin D Michos

doi:10.1161/circ.146.suppl_1.10312

Back

Abstract

Peer reviewed

Abstract 10312: Meta-Analysis of Influenza Vaccine and Cardiovascular Outcomes

Ahmad Al-Abdouh, Waiel Abusnina, Mohammed Mhanna, ahmad jabri, Anan Abu Rmilah, Taha Ahmed, Taqwa Alabduh, Mostafa Zaalouk and Erin D Michos

Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A10312-A10312

11/08/2022

DOI: 10.1161/circ.146.suppl_1.10312

View Online

Abstract

Introduction: Influenza infection is associated with increased cardiovascular morbidity and mortality. Many observational and clinical trials suggested that influenza vaccine can reduce cardiovascular outcomes. Methods: We searched EMBASE, PubMed, and Cochrane Library (inception through May 24th, 2022) for randomized controlled trials (RCTs) evaluating influenza vaccine and its association with cardiovascular outcomes. We used Mantel-Haenszel method with Paule-Mandel estimator of tau2 and Hartung-Knapp-Sidik-Jonkman adjustment (due to the small number of the included studies) to calculate the risk ratio (RR) and 95% confidence interval (CI). Results: Eight RCTs with a total of 14,420 patients were included in our analysis. Influenza vaccine as compared with control/placebo was associated with significantly lower risk of major adverse cardiovascular events (MACE) at follow-up [RR: 0.75; 95%CI: 0.57; 0.97; I2:56%] [Figure]. There was no significant difference between influenza vaccine and placebo/control in terms of all-cause mortality [RR: 0.84; 95%CI: 0.54; 1.33; I2:50%], cardiovascular mortality [RR: 0.77; 95%CI: 0.39; 1.50; I2:57%], or myocardial infarction [RR: 0.75; 95%CI: 0.52; 1.10; I2:0%]. Conclusion: Our meta-analysis suggests that influenza vaccine compared with control/placebo was associated with lower rates of MACE without a significant difference in the mortality or myocardial infarction rates.

Influenza

Cardiovascular health

Details

Title: Subtitle: Abstract 10312: Meta-Analysis of Influenza Vaccine and Cardiovascular Outcomes
Creators: Ahmad Al-Abdouh - University of Kentucky
Waiel Abusnina - Creighton University
Mohammed Mhanna - University of Toledo
ahmad jabri - cleveland, OH
Anan Abu Rmilah - Mayo Clinic in Arizona
Taha Ahmed - Cleveland Clinic
Taqwa Alabduh - Yarmouk University
Mostafa Zaalouk - Rochester General Hospital
Erin D Michos - Johns Hopkins University
Resource Type: Abstract
Publication Details: Circulation (New York, N.Y.), Vol.146(Suppl_1), pp.A10312-A10312
DOI: 10.1161/circ.146.suppl_1.10312
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins
Language: English
Date published: 11/08/2022
Academic Unit: Internal Medicine
Record Identifier: 9984845468802771

Metrics

1 Record Views