Abstract
Abstract 10595: Prognostic Value and Natural History of Cardiovascular Magnetic Resonance Derived Myocardial Extracellular Volume in Heart Transplant Patients
Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10595-A10595
11/19/2019
DOI: 10.1161/circ.140.suppl_1.10595
Abstract
IntroductionCardiac magnetic resonance (CMR) T1-mapping (T1M) parameters have prognostic implications in cardiac diseases. Recently, T1M has been studied in heart transplant (HTx) patients, however its prognostic value is still unclear.Hypothesis(1) Higher ECV would predict adverse clinical events and (2) T1M parameters would increase over time in HTx patientsMethodsThis is a prospective, longitudinal study of HTx patients who underwent baseline CMR imaging (median5 years from HTx; IQR 2, 8) and follow-up (F/U) imaging (median13 month from baseline scan; IQR 10, 23). ECV was calculated from pre-and post-contrast T1M. The primary endpoint was predefined as a composite of death, nonfatal myocardial infarction, coronary revascularization and hospitalization. Survival by ECV tertile was assessed using Kaplan-Meier-curve. Differences in event-free survival curves among patients in different ECV tertiles were compared using log-rank test. Univariate and multivariate Cox regression analysis was performed to assess the association of myocardial ECV on clinical outcomes adjusted for demographics and clinical characteristics.ResultsOf the 90 HTx patients the mean age was 50±16 years, 72% male. Events occurred in 32 patients. Median F/U for outcomes after the baseline scans was 2.4 years (IQR 1.6, 3.5). Patients with highest tertile ECV had significantly higher incidence of clinical events compared to patients with lowest tertile ECV (p=0.02). Multivariate analysis adjusted for significant CMR findings demonstrates an independent association between higher clinical event incidence with the highest ECV tertile compared to the lowest tertile (HR 2.72; CI 1.03, 7.14; p=0.04) (Fig). All T1M markers increased during follow-up assessment over the median duration of 2.4 years.ConclusionsThere is an association between higher baseline ECV and adverse clinical events. Therefore, ECV may be a useful noninvasive prognostic marker in HTx population.
Details
- Title: Subtitle
- Abstract 10595: Prognostic Value and Natural History of Cardiovascular Magnetic Resonance Derived Myocardial Extracellular Volume in Heart Transplant Patients
- Creators
- Muhannad Abbasi - Radiology, Northwestern, Chicago, ILRoberto Sarnari - Northwestern UniversityKongkiat Chaikriangkrai - 6550 Fannin Street, Houston, TXSadiya Khan - Northwestern UniversityKambiz Ghafourian - Northwestern UniversityJane Wilcox - Northwestern UniversityEsther Vorovich - Northwestern, Wilmette, ILDaniel Lee - Northwestern UniversityJonathan Rich - Northwestern UniversityAllen Anderson - Northwestern UniversityClyde Yancy - Northwestern UniversityJames carr - Northwestern UniversityMichael Markl - Northwestern University
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10595-A10595
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- DOI
- 10.1161/circ.140.suppl_1.10595
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/19/2019
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984361562402771
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