Abstract
Abstract 10596: Multiparametric Cardiac Magnetic Resonance Imaging to Detect Cardiac Allograft Vasculopathy Beyond the First Year Post-heart Transplantation
Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10596-A10596
11/19/2019
DOI: 10.1161/circ.140.suppl_1.10596
Abstract
IntroductionCardiac allograft vasculopathy (CAV) is a leading cause of mortality post-heart transplant (HTx). Invasive coronary angiography (ICA) may miss early disease. Cardiac magnetic resonance imaging (CMR) can detect changes in tissue structure (T1/T2/ECV), global (Ejection fraction, EF) and regional function (Tissue phase mapping, TPM to measure myocardial velocities).HypothesisCMR may detect biventricular (BV) alterations between HTx patients and controls, and between CAV grades.MethodsEighty-one HTx patients (mean age=50.1±15, 57% male) were prospectively recruited between August 2014-November 2018 (time after HTx6.3 yrs; IQR 3.9, 8.7) along with 18 controls (49±15 years, 66% male). Patients with poor quality/no TPM sequences (n=13) were excluded. Patients underwent CMR including cine, T1/T2-mapping, and TPM. CAV grade was based on established criteria. Regional T1, T2, and ECV were calculated using the AHA 16 segment model. TPM data analysis included calculation of BV systolic/diastolic peak myocardial velocities. Receiver operator curve analysis with areas under the curve (AUC) was used to assess diagnostic performance in CAV detection compared to ICA.ResultsDemographics and CMR parameters are reported in the Table. Parameters with highest AUCs were selected to combine (Fig).ConclusionsCombined T2, BV TPM and EF have potential for CAV assessment. Early CAV tends to cause reduced LV diastolic function by microvasculopathy, therefore diastolic velocity analysis may aid in distinguishing CAV 0 from CAV 1. Recent work indicates that severe CAV may have a vasculitic component, which may extend into the myocardium explaining elevations in T2.
Details
- Title: Subtitle
- Abstract 10596: Multiparametric Cardiac Magnetic Resonance Imaging to Detect Cardiac Allograft Vasculopathy Beyond the First Year Post-heart Transplantation
- Creators
- Muhannad Abbasi - Radiology, Northwestern, Chicago, ILRoberto Sarnari - Northwestern UniversityArif Jivan - Northwestern Memorial Hosp, Chicago, ILRahim Gulamali - Radiology, Northwestern, Chicago, ILJulie Blaisdell - Radiology, Northwestern, Chicago, ILKongkiat Chaikriangkrai - 6550 Fannin Street, Houston, TXAlexander Ruh - Radiology, Northwestern, Chicago, ILDaniel Lee - Northwestern UniversityKambiz Ghafourian - Northwestern UniversityJane Wilcox - Northwestern UniversitySadiya Khan - Northwestern UniversityEsther Vorovich - Cardiology, Northwestern, Chicago, ILJonathan Rich - Northwestern UniversityAllen Anderson - Northwestern UniversityClyde Yancy - Northwestern UniversityJames carr - Northwestern UniversityMichael Markl - Northwestern University
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10596-A10596
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- DOI
- 10.1161/circ.140.suppl_1.10596
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/19/2019
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984361860102771
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