Abstract
Abstract 10789: Effect of Sacubitril-Valsartan on Incidence of Atrial Fibrillation: A Meta-Analysis
Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A10789
11/16/2021
DOI: 10.1161/circ.144.suppl_1.10789
Abstract
Introduction:
Sacubitril/valsartan reduces all cause mortality in heart failure (HF) patients compared to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). ACEIs/ARBs have been shown to decrease the incidence of atrial fibrillation (AF).
Hypothesis:
Sacubitril-Valsartan decreases the incidence of AF compared to ACEis/ARBs.
Methods:
Clinicaltrials.gov was searched for trials by terms sacubitril/valsartan, entresto, sacubitril, valsartan. Randomized controlled human trials of sacubitril/valsartan reporting AF were included. Data were extracted independently by two reviewers. Data was pooled using a random effect model. Publication bias was evaluated by funnel plots.
Results:
A total of 11 trials including 11474 patients on sacubitril/valsartan and 10145 patients on ACEI/ARBs were identified. 304 AF events were reported in the sacubitril/valsartan group compared to 284 AF events in ACEIs/ARBs. Patients on sacubitril/valsartan were as likely as patients on ACEIs/ARBs to develop AF (pooled OR=1.054, (95% CI= 0.893 - 1.244), p=0.536). Atrial flutter (AFl) events were reported in 6 trials; 48 out of 9165 patients in the sacubitril/valsartan group developed AFl compared to 46 out of 8759 in ACEi/ARBs group. There was no difference in AFl risk between the two groups (pooled OR=1.028, (95% CI=0.681 - 1.553), p=0.894). Finally, sacubitril/valsartan did not reduce the risk of atrial arrhythmias (AF+AFl) compared to ACEi/ARBs (pooled OR=1.050 (95% CI= 0.900 - 1.225), p=0.533).
Conclusion:
Although sacubitril/valsartan reduces mortality compared to ACEIs/ARBs in HF patients, they do not reduce AF risk compared to these drugs.
Details
- Title: Subtitle
- Abstract 10789: Effect of Sacubitril-Valsartan on Incidence of Atrial Fibrillation: A Meta-Analysis
- Creators
- Javaria Ahmad - Shreveport, LAAli Sultan - LAPaari Dominic - LSUHSC Shreveport, Shreveport, LA
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.144(Suppl_1), p.A10789
- DOI
- 10.1161/circ.144.suppl_1.10789
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/16/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367230102771
Metrics
1 Record Views