Abstract
Abstract 10876: Risk of Morbidity and Mortality in Takotsubo Cardiomyopathy With Right Ventricular Involvement - A Meta-analysis of Observational Trials
Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10876-A10876
11/19/2019
DOI: 10.1161/circ.140.suppl_1.10876
Abstract
BackgroundThe studies to date have reported conflicting results on the risk of mortality in Takotsubo cardiomyopathy (TTS) with right ventricular involvement (RV) when compared to TTS without RV. We conducted a meta-analysis to evaluate the risk and trends in mortality and morbidity between the two groups.MethodA comprehensive review of the literature was performed in PubMed and EMBASE. Studies were included if they reported either in-hopsital mortality, long term all-cause mortality, incidence of acute heart failure or duration of hospital stay. We reported odds ratio as a measure of outcome.Results168 studies were identified for screening, of which 10 studies were included in the analysis. Based on the random effect model, the odds of in-hospital mortality and long-term mortality after a mean duration of follow-up of 31 weeks in TTS without RV compared to TTS with RV were 0.47 (95% confidence interval of 0.18 to 1.25, p=0.13) (Fig 1a) and 0.69 (95% confidence interval of 0.28 to 1.67, p=0.40) (Fig 1b). The mean duration of hospitalization was longer in TTS with RV 7.6 vs 9.5 days. The odds of acute heart failure in TTS without RV group was 0.26 (P<0.0001) (Fig 1c). Similarly, the odds of tricuspid and mitral regurgitation were lower in TTS without RV of 0.52 (P=0.02) and 0.40 (P=0.0001) (Table 1). Left ventricular ejection fraction percentage was significantly reduced in with RV group (41% vs 34%, p=0.03).ConclusionIn this meta-analysis of observational trials, we found that although there was a trend towards increased risk of mortality in TTS with RV involvement, the risk of in-patient mortality and long-term all-cause mortality from TTS with RV involvement did not differ when compared to the TSS with left ventricle failure alone. The duration of hospital stay did not differ between the two groups. Although, TTS with RV involvement showed increased risk for acute heart failure, tricuspid, mitral regurgitation and decreased LVEF.
Details
- Title: Subtitle
- Abstract 10876: Risk of Morbidity and Mortality in Takotsubo Cardiomyopathy With Right Ventricular Involvement - A Meta-analysis of Observational Trials
- Creators
- Suchith Shetty - University of IowaAaqib Malik - Westchester Medical CenterKan Liu - University of Iowa
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.140(Suppl_1 Suppl 1), pp.A10876-A10876
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- DOI
- 10.1161/circ.140.suppl_1.10876
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/19/2019
- Academic Unit
- Cardiovascular Medicine; Internal Medicine; Radiology
- Record Identifier
- 9984320009202771
Metrics
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