Abstract
Abstract 11697: Sex Differences in the Use of Statins in Community Practice: The PALM Registry
Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A11697-A11697
11/06/2018
Abstract
BackgroundWomen have historically received less aggressive lipid management than men. Whether these sex differences persist in contemporary community care is unclear.MethodsUsing the PALM Registry, a nationwide registry of outpatients with or at risk for cardiovascular disease (CVD) during 2015, we evaluated use of statin therapy, guideline-recommended statin dosing, and reasons for under-treatment in women and men. Using logistic regression, we also analyzed sex differences in statin treatment after adjusting for, demographics, clinical, socioeconomic, patient beliefs (about statins, cholesterol, and their physicians), and provider factors.ResultsAmong 5618 participants (43% women) eligible for 2013 ACC/AHA cholesterol guideline-recommended primary (n=2488, 52% women) or secondary prevention (n=3130, 36% women) statin therapy, women were less likely to be treated with a statin than men (67% vs. 78%, p<0.001) or to receive a guideline-recommended statin intensity (35% vs 44%, p<0.001). These sex differences in use of statins persisted after adjustment (any statin treatmentadjusted OR=0.71, 95% CI 0.62-0.82, p<0.001; guideline-recommended statin intensityadjusted OR=0.83, 95% CI 0.73-0.94, p<0.01). Sex differences were consistent across both primary and secondary prevention sub-groups. Women were less likely than men to believe statins were safe (47.9% vs. 55.2%%, p<0.001) or effective (67.9% vs. 73.1%, p<0.001). Women were more likely than men to report having discontinued a statin (11.0% vs. 6.2%, p<0.001), discontinue a statin due to side effects (7.9% vs. 4.0%, p<0.001), or never be offered a statin (18.7% vs. 13.7%, p<0.001) (Figure).ConclusionsWomen eligible for statin therapy are less likely than men to receive any therapy or have the correct intensity treatment. These sex differences appear to stem from women being less likely to be offered statin therapy as well as women having lower beliefs in statin safety and efficacy that may lead to them declining or discontinuing statin therapy.
Details
- Title: Subtitle
- Abstract 11697: Sex Differences in the Use of Statins in Community Practice: The PALM Registry
- Creators
- Michael Nanna - Duke UniversityTracy Wang - Duke UniversityQun Xiang - Duke UniversityAnn Goldberg - Endocrinology, Washington Univ. Sch of Medicine, St. Louis, MOJennifer Robinson - University of IowaVeronique Roger - Winneshiek Medical CenterSalim Virani - Baylor College of MedicinePeter Wilson - Emory and Henry CollegeMichael Louie - RegeneronAndrew Koren - SanofiEric Peterson - Duke UniversityAnn Navar - Duke University
- Resource Type
- Abstract
- Publication Details
- Circulation (New York, N.Y.), Vol.138(Suppl_1 Suppl 1), pp.A11697-A11697
- Publisher
- by the American College of Cardiology Foundation and the American Heart Association, Inc
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/06/2018
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984364379102771
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